Napoli vs. Sassuolo (Saturday, 2.00pm)
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Days after establishing a new club record with their 12th straight win, Napoli aim to extend that streak at home to Sassuolo on Saturday afternoon.
The Serie A leaders continue their Scudetto quest at Stadio Maradona, where they crushed Rangers 3-0 in midweek, and now face a mid-table side desperately seeking some consistency.
We say: Napoli 2-0 Sassuolo
As Sassuolo have scored just four times in five away games so far, breaching a tight Napoli defence will prove a particular challenge. Given it is almost inevitable the hosts will score at least once, as they welcome back several stars from a midweek rest, the Serie A leaders' golden run should continue.
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Lecce vs. Juventus (Saturday, 5.00pm)
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Following their midweek exit from Europe, an ailing Juventus side return to Serie A duty on Saturday, as they visit lowly Lecce at Stadio Via del Mare.
Beaten for the fourth time in five Champions League games, Juve are now set to drop into the Europa League, but first must make up ground on the seven clubs above them in Italy, as they seek a third league win on the spin.
We say: Lecce 0-1 Juventus
Only Lazio have kept more clean sheets than Juve's six in Serie A this season; Lecce are one of two sides yet to post a single shutout. Therefore, even if the visitors experience a Champions League hangover, they can score at least once at Via del Mare - if only from a set piece.
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Inter Milan vs. Sampdoria (Saturday, 7.45pm)
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After securing their spot in the Champions League's last-16, Inter Milan return to Serie A duty on Saturday night, as they aim to make up lost ground by beating struggling Sampdoria.
While Inter cruised to a fifth win from six matches in midweek, Samp scrapped out their first league victory of the season at Cremonese, and now former Nerazzurri star Dejan Stankovic returns to San Siro seeking a major upset.
We say: Inter Milan 2-0 Sampdoria
Inter are drawless in their last 20 league games - their longest such run since the 1940s - while Samp have scored the fewest Serie A goals this season. Not surprisingly, then, a home win appears to be on the cards, with Lukaku's return occurring just in time to match a Martinez hot-streak.
