The Baltimore Ravens won their first home game since winning the Super Bowl, beating the Atlanta Falcons 27-23.
Joe Flacco only played in the first quarter, but was able to find Torrey Smith with a 77-yard touchdown pass to give the Ravens an early lead.
Touchdowns from Julio Jones and Jacquizz Rodgers got the NFC South side back into the game, but backup quarterback Tyrod Taylor helped the Ravens find the end zone three times in the fourth quarter to secure a narrow win.
Michael Vick and Nick Foles'a competition for the starting quarterback job with the Philadelphia Eagles continued as the NFC East side beat the Carolina Panthers.
Vick completed nine of his 10 passing attempts for 105 yards, but also threw an interception, while Foles had six completions from eight attempts for 53 yards and an interception.
Foles also found the end zone with a seven-yard rush in the opening quarter, while LeSean McCoy scored the game's only other touchdown with a one-yard burst just before half time.
Brandon Weeden completed two touchdown passes to help the Cleveland Browns to a comfortable 24-6 win over the Detroit Lions.
Tight end Jerome Cameron was on the receiving end of both passes, before running back Brandon Jackson added a third Browns touchdown in the fourth.
The Lions were without single-season receiving yards record holder Calvin Johnson, who was rested after bruising his knee in training camp.
The Chicago Bears survived a strong second half from the San Diego Chargers to take a narrow win over the AFC West side.
Brandon Marshall and Matt Forte scored first-quarter touchdowns, before Robbie Gould added a pair of field goals in the second quarter, leaving the Bears 20-7 ahead of half time.
The Chargers scored three touchdowns, including two from Mike Willie, in the second half, but further kicks from Gould ensured that the Bears remained ahead.
Results in full: Atlanta Falcons 23-27 Baltimore Ravens, Detroit Lions 6-24 Cleveland Browns, Carolina Panthers 9-14 Philadelphia Eagles, San Diego Chargers 28-33 Chicago Bears
