The NFL has announced that it will increase the number of matches played in the UK from three to four next season.
Three regular-season games have been played in London every season since 2014, predominantly at Wembley, although Twickenham was used as a venue for the first time this year.
"We continue to be incredibly excited by the passion and love for the NFL shown by our millions of UK fans," said NFL Commissioner Roger Goodell. "London is an amazing city. We have had tremendous support from our fans, from Mayor Khan and other government leaders and business partners, and we are looking forward to taking the next step in the UK by playing four games in London next season."
London mayor Sadiq Khan added: "London staging a fourth NFL game is fantastic news – not only for the millions of sports fans who get to enjoy our iconic stadiums – but also because it confirms our status as the go-to choice for hosting the world's biggest sporting events.
"London is the international home of the NFL and staging the equivalent of what would be half an American football team's home games in the city is a huge step towards my ambition of bringing a franchise to the capital.
"I am really excited to welcome more NFL teams to London next year, as well as thousands of American football fans from around the globe, showing that London is open to the very best sporting events and the world's greatest athletes."
The venues and teams participating in the four games will be announced on Tuesday.