Gloucestershire Gladiators claimed a five-wicket win over Middlesex Panthers, leaving the visitors without a win in the T20 Blast so far this season.
John Simpson led Middlesex with the bat, finishing his innings with 22 not out, but was the only batsman to add more than 20, setting Gloucester a target of just 112 for victory.
The hosts reached the total with almost three overs to spare, led by Christopher Dent and Hamish Marshall.
Kent Spitfires got their season off the a winning start with a 42-run win over Somerset.
Rain forced the match to be cut to 13-over innings, but a half-century from Daniel Bell-Drummond helped Kent post a total of 164.
James Hildreth finished 58 not out in reply for Somerset, but Douglas Bollinger frustrated the batsman, finishing with figures of 3-36.
Hampshire secured their first win of the competition, beating Sussex Sharks by 18 runs.
The visitors won the toss and chose to bat, with a half-century from James Vince at the top of the batting order setting Hampshire up for a total of 177.
After a slow start to the home side's reply, Ed Joyce and Rory Hamilton-Brown had a 25-run partnership, but it was not enough to avoid the defeat.
Essex Eagles beat Glamorgan's total with just two balls to spare to make it two wins from two in the T20 Blast, leaving them at the top of the South Group.
A 96-run stand for the opening wicket from Jacques Rudolph and James Allenby appeared to have left Glamorgan in a strong position, but Essex's middle order were in dominant form to pass their 190-run target in the final over.
Worcestershire Rapids cruised to a 24-run win over Nottinghamshire Outlaws to seal their first win of the season and move up to fifth in the North Group.
After a shaky start, Colin Muroe, Alexei Kervezee and Ross Whiteley all made runs to leave the Outlaws needing 164 for victory.
Nottinghamshire started their replay well, but Christopher Russell ripped through the lower order to ensure that they did not reach their target.
Northamptonshire Steelbacks moved to the top of the North Group table with a two-wicket win over Leicestershire Foxes.
Joshua Cobb hit 77 while Greg Smith also picked up a half-century as Leicestershire posted a total of 176-4 off 18 overs in a match reduced by rain.
Northamptonshire stuttered as they neared their target, but Graeme White hit the winning runs off the final over to clinch the win.
Lancashire Lightning eased to a 20-run win over Derbyshire Falcons to maintain their unbeaten start to the season.
The Lightning struggled early on as they were reduced to 38-3 in just over five overs, but Karl Brown and Steven Croft finished with an unbeaten stand of 131 runs.
Stephen Moore made a strong start to Derbyshire's reply, but Kabir Ali finished the day with 3-27 to restrict the rest of the batsmen.
The match between Birmingham Bears and Yorkshire Vikings was abandoned without a ball being bowled because of the inclement weather.
Results in full: Gloucestershire beat Middlesex by five wickets, Kent beat Somerset by 42 runs, Hampshire beat Sussex by 18 runs, Essex beat Glamorgan with four wickets, Worcestershire beat Nottinghamshire by 24 runs, Northamptonshire beat Leicestershire by two wickets, Lancashire beat Derbyshire by 20 runs, Warwickshire against Yorkshire abandoned
