Leeds defender Diego Llorente will miss Spain's Nations League game in Ukraine on Tuesday due to injury.
Llorente, signed by Leeds from Real Sociedad for a reported £18million last month, and Villarreal striker Gerard Moreno have both withdrawn from Spain's squad.
The Spanish Football Association said in a statement that both players were suffering from muscle problems and had left the camp.
Llorente, who has yet to make his Leeds debut, was an unused substitute in Spain's 1-0 win against Switzerland on Sunday.
The 27-year-old had played the full 90 minutes in Spain's goalless draw against Portugal in a friendly on Thursday.
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