The Honduran was taken off after he had played a significant part in creating the second goal of United's 2-0 victory, scored by Javier Hernandez.
He is now expected to miss up to four weeks, according to the club's official website.
United host Ajax at Old Trafford in the second leg next Thursday.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Liverpool | 29 | 21 | 7 | 1 | 69 | 27 | 42 | 70 |
| 2 | Arsenal | 29 | 16 | 10 | 3 | 53 | 24 | 29 | 58 |
| 3 | Nottingham ForestNott'm Forest | 29 | 16 | 6 | 7 | 49 | 35 | 14 | 54 |
| 4 | Chelsea | 29 | 14 | 7 | 8 | 53 | 37 | 16 | 49 |
| 5 | Manchester CityMan City | 29 | 14 | 6 | 9 | 55 | 40 | 15 | 48 |
| 6 | Newcastle UnitedNewcastle | 28 | 14 | 5 | 9 | 47 | 38 | 9 | 47 |
| 7 | Brighton & Hove AlbionBrighton | 29 | 12 | 11 | 6 | 48 | 42 | 6 | 47 |
| 8 | Fulham | 29 | 12 | 9 | 8 | 43 | 38 | 5 | 45 |
| 9 | Aston Villa | 29 | 12 | 9 | 8 | 41 | 45 | -4 | 45 |
| 10 | Bournemouth | 29 | 12 | 8 | 9 | 48 | 36 | 12 | 44 |
| 11 | Brentford | 29 | 12 | 5 | 12 | 50 | 45 | 5 | 41 |
| 12 | Crystal Palace | 28 | 10 | 9 | 9 | 36 | 33 | 3 | 39 |
| 13 | Manchester UnitedMan Utd | 29 | 10 | 7 | 12 | 37 | 40 | -3 | 37 |
| 14 | Tottenham HotspurSpurs | 29 | 10 | 4 | 15 | 55 | 43 | 12 | 34 |
| 15 | Everton | 29 | 7 | 13 | 9 | 32 | 36 | -4 | 34 |
| 16 | West Ham UnitedWest Ham | 29 | 9 | 7 | 13 | 33 | 49 | -16 | 34 |
| 17 | Wolverhampton WanderersWolves | 29 | 7 | 5 | 17 | 40 | 58 | -18 | 26 |
| 18 | Ipswich TownIpswich | 29 | 3 | 8 | 18 | 28 | 62 | -34 | 17 |
| 19 | Leicester CityLeicester | 29 | 4 | 5 | 20 | 25 | 65 | -40 | 17 |
| 20 | Southampton | 29 | 2 | 3 | 24 | 21 | 70 | -49 | 9 |
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