The Manchester United forward is reported to be struggling with groin and toe problems.
Van Persie is the all-time leading goalscorer for his country with 41 goals in 81 matches.
The Netherlands face Japan in Genk on Saturday before entertaining Colombia in Amsterdam three days later.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Liverpool | 32 | 23 | 7 | 2 | 74 | 31 | 43 | 76 |
| 2 | Arsenal | 32 | 17 | 12 | 3 | 57 | 27 | 30 | 63 |
| 3 | Newcastle UnitedNewcastle | 32 | 18 | 5 | 9 | 61 | 40 | 21 | 59 |
| 4 | Nottingham ForestNott'm Forest | 32 | 17 | 6 | 9 | 51 | 38 | 13 | 57 |
| 5 | Manchester CityMan City | 32 | 16 | 7 | 9 | 62 | 42 | 20 | 55 |
| 6 | Chelsea | 32 | 15 | 9 | 8 | 56 | 39 | 17 | 54 |
| 7 | Aston Villa | 32 | 15 | 9 | 8 | 49 | 46 | 3 | 54 |
| 8 | Bournemouth | 32 | 13 | 9 | 10 | 52 | 40 | 12 | 48 |
| 9 | Fulham | 32 | 13 | 9 | 10 | 47 | 43 | 4 | 48 |
| 10 | Brighton & Hove AlbionBrighton | 32 | 12 | 12 | 8 | 51 | 49 | 2 | 48 |
| 11 | Brentford | 32 | 12 | 7 | 13 | 52 | 48 | 4 | 43 |
| 12 | Crystal Palace | 32 | 11 | 10 | 11 | 41 | 45 | -4 | 43 |
| 13 | Everton | 32 | 8 | 14 | 10 | 34 | 38 | -4 | 38 |
| 14 | Manchester UnitedMan Utd | 32 | 10 | 8 | 14 | 38 | 45 | -7 | 38 |
| 15 | Tottenham HotspurSpurs | 32 | 11 | 4 | 17 | 60 | 49 | 11 | 37 |
| 16 | Wolverhampton WanderersWolves | 32 | 10 | 5 | 17 | 47 | 61 | -14 | 35 |
| 17 | West Ham UnitedWest Ham | 32 | 9 | 8 | 15 | 36 | 54 | -18 | 35 |
| 18 | Ipswich TownIpswich | 32 | 4 | 9 | 19 | 33 | 67 | -34 | 21 |
| 19 | Leicester CityLeicester | 32 | 4 | 6 | 22 | 27 | 72 | -45 | 18 |
| 20 | Southampton | 32 | 2 | 4 | 26 | 23 | 77 | -54 | 10 |
| > Premier League Full Table | |||||||||
