Tottenham Hotspur head coach Tim Sherwood will demand a response from his side after they fell to disappointing results against Chelsea and Benfica over the past seven days.
Spurs capitulated against the Blues at Stamford Bridge last weekend before being outclassed by Benfica in the Europa League, leaving the club to place their focus on qualifying for Europe next season.
Sherwood could recall Roberto Soldado for the clash with their North London rivals, while Danny Rose may return at full-back in place of either Kyle Walker or Kyle Naughton.
Arsenal return to league action after bowing out of the Champions League in midweek with a 1-1 draw at Bayern Munich.
Arsene Wenger's injury-hit squad could take positives from the fixture in Germany, but they will be without Mesut Ozil for at least four weeks after the German midfielder picked up a hamstring injury.
Tomas Rosicky is likely to replace Ozil, while goalkeeper Wojciech Szczesny should regain his starting spot.
Recent form
Tottenham Hotspur: LLWWLL
Arsenal: WLWLWD
Possible starting lineups
Tottenham Hotspur: Lloris; Walker, Rose, Kaboul, Vertonghen; Sandro, Lennon, Paulinho, Eriksen; Adebayor, Soldado
Arsenal: Szczesny; Sagna, Vermaelen, Mertesacker, Koscielny; Arteta, Oxlade-Chamberlain, Flamini, Rosicky, Cazorla; Giroud
Sports Mole says: 1-2
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