Alex Corbisiero has been replaced by Joe Marler for England's third Test against South Africa after the prop was ruled out with a knee injury.
The 23-year-old was originally included in head coach Stuart Lancaster's side but since suffering the blow, Harlequins' Marler has been called on to finish off the series, which England have already lost.
Saturday's clash against the Springboks will be a big ask for Marler, who made his debut in England's 22-17 defeat in the series opener.
Meanwhile, Paul Doran-Jones has been added to the bench following the inclusion of the 21-year-old.