NFL side St Louis Rams have decided not to travel to London for one of their eight home matches in 2013 and 2014.
The Rams will honour their arrangement to compete against New England Patriots in October this year but may not feature in the NFL International Series again.
The team said in a statement to the NFL's official website: "In an effort to focus on the Edward Jones Dome First Tier Process with the St. Louis Convention and Visitors Commission, the St. Louis Rams are withdrawing their commitment to play a home game in London in each of the 2013 and 2014 seasons.
"The St. Louis Rams will play the New England Patriots on Sunday, October 28, 2012 at London's historic Wembley Stadium as previously announced."
Wembley has hosted the International Series in each of the last five seasons from 2007-2011.