Lecce have sacked Eusebio Di Francesco and appointed Serse Cosmi as their new manager.
Di Francesco took over at the club over the summer, but a poor start to the season has left the side bottom of the Serie A table.
"US Lecce announce the collaboration with Eusebio Di Francesco has been resolved today. We wish to express a sincere thanks for the work done until now," read a club statement.
"US Lecce also confirm an agreement has been reached with Serse Cosmi to take control of the first team."
Cosmi, 53, was last in club management with Palermo before he was sacked earlier this year.