Tottenham Hotspur striker Harry Kane is in line to start for the first time in the Premier League this season when Nuno Espirito Santo's side host Watford on Sunday.

The 28-year-old, who played for 73 minutes and scored a brace in Thursday's Europa Conference League second-leg victory against Pacos de Ferreira, is set to replace Steven Bergwijn, who started against Wolverhampton Wanderers last weekend.

Son Heung-min and Lucas Moura are expected to join Kane in a three-man attack, while Dele Alli – who scored the only goal in Tottenham's 1-0 win at Molineux – could keep his place in an advanced midfield role, playing just in front of Oliver Skipp and Pierre-Emile Hojbjerg.

Hugo Lloris, Sergio Reguilon and Japhet Tanganga are all set to return to the starting lineup after being rested in midweek, while club-record signing Cristian Romero will be hoping he can start his first league game for Spurs at centre-back ahead of either Davinson Sanchez or Eric Dier.

Pierluigi Gollini, Ryan Sessegnon, Harry Winks, Giovani Lo Celso and Bryan Gil all started on Thursday, though they are set to drop to the bench for this weekend's game.

Defenders Cameron Carter-Vickers and Joe Rodon will both be absent due to injury, though the latter is close to a full recovery and could be available for next month's clash against Crystal Palace.

French midfielder Tanguy Ndombele will not be involved in the squad amid speculation surrounding his future, while Moussa Sissoko has completed his move from Spurs to Watford, though he is unlikely to make his debut for the Hornets on Sunday.

Tottenham possible starting lineup: Lloris; Tanganga, Sanchez, Dier, Reguilon; Hojbjerg, Skipp, Dele; Lucas, Kane, Son