Former Cheltenham Gold Cup winner Denman has been retired following an injury suffered in preparation for his return later this month.
The 11-year-old was scheduled to race in the Lexus Chase taking place at Leopardstown on December 28 but trainer Paul Nicholls has called time on his career after suffering a tendon injury.
"Denman was great on Wednesday morning as he worked towards his intended start in the Lexus later this month, but he pulled up a little bit sore yesterday morning and Clifford wasn't happy with him," Nicholls explained in his Betfair column.
"It was the only course of action to take."
Denman will be remembered for his rivalry with Kauto Star, the horse who won the Cheltenham World Cup either side of Denman's triumph in 2008.