Salernitana vs. Torino (Sunday, 11.30am)
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After three straight defeats either side of the World Cup break, Salernitana attempt to stop their slide down the Serie A standings on Sunday, when they welcome Torino to Stadio Arechi.
Coach Davide Nicola takes on his former club having seen his side pick up just one point since October, while Toro travel south on the back of a disappointing home draw.
We say: Salernitana 1-1 Torino
Both sides will see this game as a potential three points to be bagged against opponents of similar standing in Serie A this season, and a close-fought contest should end with the spoils shared. Neither team is prolific and both are well-organised, so a low-scoring draw is on the cards.
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Lazio vs. Empoli (Sunday, 2.00pm)
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Following a calamitous collapse in midweek, Lazio aim to kickstart their campaign with a win on Sunday, as they host mid-table Empoli at Stadio Olimpico.
Conceding twice in the second half at Lecce, the capital city club lost their second straight Serie A fixture either side of the winter break; while their visitors took a hard-earned point home from Udine to tally seven from their last four games.
We say: Lazio 2-0 Empoli
One win and six goals from eight road trips this term means that Empoli offer a prime opportunity for Lazio to halt their losing streak, as they finally return to Rome. Due to some fans' racist abuse of Lecce players on Wednesday, the notorious Curva Nord will be closed at Stadio Olimpico, but the home side should still prevail.
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Spezia vs. Lecce (Sunday, 2.00pm)
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Lecce will be aiming to win a fourth successive league match when they visit Spezia in Serie A on Sunday.
The hosts, meanwhile, will hope to put further distance between themselves and the relegation zone.
We say: Spezia 1-2 Lecce
Spezia's collapse against Atalanta would have concerned their manager Gotti, who is likely to be forced into starting an inexperienced youngster in goal due to injuries.
As such, we would not be surprised if Lecce extend their winning run to four matches on Sunday.
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Sampdoria vs. Napoli (Sunday, 5.00pm)
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Just days after their first defeat of the Serie A season, Napoli aim to resume normal service against Sampdoria on Sunday, as the teams meet at Stadio Luigi Ferraris.
Beaten 1-0 by potential title rivals Inter in Milan, the leaders move on to Genoa this weekend, where they encounter a Samp side celebrating just their second league win this term.
We say: Sampdoria 0-1 Napoli
After their attack was finally kept quiet for a full 90 minutes on Wednesday, surely Napoli will find the net at Marassi, given their hosts' defensive woes. Showing signs of improvement - albeit from a very low base - Samp can put up a stern resistance to the Serie A leaders but will still succumb in the end.
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AC Milan vs. Roma (Sunday, 7.45pm)
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After both enjoyed winning returns to action in midweek, second-placed AC Milan and a Roma side trailing six points below them in the Serie A standings meet at San Siro on Sunday.
Two heavyweights of Calcio need another victory for their own particular aims, with the champions aiming to further reduce their deficit to Napoli and their visitors from the capital seeking to push on in pursuit of a top-four place.
We say: AC Milan 2-1 Roma
Following Napoli's first slip-up, Milan will scent blood - and they now face a Roma side renowned for flunking against their top-six rivals.
In an intriguing clash of styles - the Rossoneri have scored the most open play goals in Serie A this season (28); the Giallorossi boast the best percentage from set-pieces (42%) - it is the home side that should come out on top.