AFC Wimbledon vs. Lincoln (Saturday, 3.00pm)
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AFC Wimbledon will look to put an end to a 17-game league winless run on Saturday, when they entertain Lincoln City.
A dismal run has seen the Dons fall to 20th spot in the League One table, now just one point above the relegation zone.
We say: AFC Wimbledon 1-2 Lincoln City
Both sides find themselves in poor runs recently, but Lincoln's performance against an in-form Sheffield Wednesday side tips the balance in their favour in our view.
We expect Appleton's side, who boast more quality than their standing suggests, to triumph against the team with the division's longest winless run.
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Accrington vs. Charlton (Saturday, 3.00pm)
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Charlton Athletic will look to put an end to a six-game league winless run on Saturday, when they travel to take on Accrington Stanley.
A difficult spell of form has seen the Addicks drop to 16th spot in the League One table, while their hosts are six points better off and occupy the final place in the top half.
We say: Accrington Stanley 1-2 Charlton Athletic
While a stalemate may seem likely in this meeting, Accrington's positive approach means they usually come out as either triumphant winners or heavy losers, and we have a feeling they will fall short.
Charlton have certainly been off the pace this season, but an improved result last time out may at least inspire a slight uplift, and they still boast the quality to get over the line this weekend.
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Bolton vs. Plymouth (Saturday, 3.00pm)
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Having now climbed back into the top six of the League One table, Plymouth Argyle will look to give their playoff hopes another boost on Saturday, when they travel north to take on Bolton Wanderers.
The Pilgrims made it back-to-back league victories on Tuesday, while their hosts snatched a point against Morecambe.
We say: Bolton Wanderers 1-1 Plymouth Argyle
Plymouth Argyle will certainly be focussed on earning another victory to boost their playoff claim, but they face a particularly tough test, and we do not see them returning to the south coast with all three points.
Instead, we expect two strong sides to cancel one another out in Lancashire and share the spoils.
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Burton Albion vs. Fleetwood (Saturday, 3.00pm)
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Burton Albion and Fleetwood Town will do battle at the Pirelli Stadium on Saturday, as both sides look to end poor runs of form.
The two teams have each lost their last three games, while the visitors have gone 10 matches without a win, seeing them fall within a point of the relegation zone in the League One table.
We say: Burton Albion 2-2 Fleetwood Town
Given both sides' struggles for victories recently, we see a draw as the most likely outcome.
They will each see it as a good opportunity to reverse their fortunes and chances could be abundant, given their shared defensive frailties, but we ultimately expect them to cancel one another out.
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Doncaster vs. Gillingham (Saturday, 3.00pm)
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A crucial battle at the bottom end of the League One table will take place at the Keepmoat Stadium on Saturday, as Doncaster Rovers entertain Gillingham.
The two sides currently sit 23rd and 22nd, four and three points adrift of safety respectively.
We say: Doncaster Rovers 2-1 Gillingham
Given the major importance of the meeting in the battle for survival, we expect this to be a cagey affair and just give the edge to the hosts.
McSheffrey's side have looked far more competent recently, and, if they are able to lift the mood in the camp after a heavy defeat, they could have enough to secure all three points with home advantage.
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Ipswich vs. Portsmouth (Saturday, 3.00pm)
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Ipswich Town play host to Portsmouth on Saturday afternoon with just two points separating the clubs in the League One standings.
However, while the Tractor Boys and Pompey remain as outsiders for the playoffs, they head into the fixture at Portman Road as two of the form teams in the division.
We say: Ipswich Town 1-1 Portsmouth
Given their form and what is at stake, this is the most anticipated match in the division over the weekend, and we expect a game full of quality to play out. However, both teams could cancel each other out, leading to a draw that does not necessarily help either club.
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MK Dons vs. Wigan (Saturday, 3.00pm)
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A crucial contest in the battle for promotion will take place at Stadium MK, when third-placed MK Dons face Wigan Athletic, who currently sit in second position.
Although both sides are level on 72 points, Wigan have the advantage of possessing three games in hand over Saturday's opponents.
We say: MK Dons 2-1 Wigan Athletic
Both sides are in impressive form, but after winning their last five matches, we think MK Dons will have the edge over the Latics and a victory on Saturday would see the Dons claim a league double over Wigan.
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Morecambe vs. Cheltenham (Saturday, 3.00pm)
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Morecambe have the chance to climb out of the League Two relegation zone on Saturday when they host Cheltenham Town at Globe Arena.
The visitors only managed two victories in their previous six fixtures, which is something that they will be hoping to improve upon as they sit just outside of the top half.
We say: Morecambe 1-1 Cheltenham Town
Morecambe need to start picking up some points in order to fight against relegation, and that is something they have been doing, with several draws taking place.
Considering the fact that Cheltenham Town have been quite inconsistent as of late, this could be another opportunity for the Shrimps to earn a point.
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Sheff Weds vs. Cambridge (Saturday, 3.00pm)
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Sheffield Wednesday shall be hoping to return to the playoff places on Saturday after they host Cambridge United in their latest League One clash, with the visitors aiming to move to the top half.
Both teams have plenty to fight for in regards to their own respective seasons, and each will be wanting to get back to winning ways after their previous outings.
We say: Sheffield Wednesday 2-0 Cambridge United
Sheffield Wednesday have been in fine form overall lately, despite their recent slip-up, and Moore's men will be looking for an immediate response.
Facing a Cambridge United team who have struggled to score in their previous outings, the Owls will have the confidence that they can secure three points on Saturday.
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Shrewsbury vs. Oxford Utd (Saturday, 3.00pm)
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Oxford United's continued pursuit of a place in the second tier will continue this weekend, with the U's set to face Shrewsbury Town on Saturday afternoon.
For Shrewsbury, they look destined for a comfortable mid-table finish, but will be keen to stunt the progression of high-flyers Oxford.
We say: Shrewsbury Town 1-3 Oxford United
Oxford will be hoping by the time that next season rolls around they will be plying their trade in the Championship.
For Shrewsbury, League One is as good as it is going to get for now, and they will likely succumb yet again to the promotion chasers.
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Sunderland vs. Crewe (Saturday, 3.00pm)
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Sunderland will look to extend their unbeaten to five matches, when they welcome Crewe Alexandra to the Stadium of Light on Saturday.
The visitors, meanwhile, sit bottom of the pile in League One after losing nine of their last 10 matches.
We say: Sunderland 3-0 Crewe Alexandra
With Sunderland unbeaten in their last four matches, we think the hosts will make light work of a Crewe side, who are bereft of confidence after losing nine of thier previous 10 games.
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Wycombe vs. Rotherham (Saturday, 3.00pm)
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After booking their place at Wembley for the EFL Trophy final, League One leaders Rotherham United will be looking to claim all three points at Adams Park when they lock horns with Wycombe Wanderers on Saturday.
The Chairboys have only won one of their last five games on home soil, while the Millers are unbeaten in each of their last seven matches on the road.
We say: Wycombe Wanderers 1-2 Rotherham United
A couple of weeks ago, Rotherham would have been rubbing their hands at this fixture given Wycombe's poor run of form; however, the Chairboys have since turned their fortunes around, while the Millers have suffered a slight dip, so Saturday's contest is set to be a closely-fought contest.
Nevertheless, we feel that the visitors will do just enough to claim a slender victory away from home and boost their title hopes.