Farense vs. Vizela (Saturday, 3.30pm)
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Vizela travel south to the Algarve to face SC Farense at the Estadio de Sao Luis in the Primeira Liga on Saturday afternoon.
Just one point separates the two sides in 12th and 14th, in what is a very tight bottom half in Portugal's top flight.
We say: SC Farense 2-1 Vizela
Home form is set to be vital in the fight against relegation, and Farense have already shown they are capable of picking up big wins here.
Vizela escaped with a draw in their last away outing, but their form on the road over the past few months has been woeful, and they may fall to another defeat here.
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Chaves vs. Gil Vicente (Saturday, 3.30pm)
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Bottom-of-the-table Chaves host a Gil Vicente side currently sat at the bottom of the top half in the Primeira Liga on Saturday.
Chaves appear to be turning a corner under new management after a truly shocking start to the season.
We say: Chaves 3-2 Gil Vicente
In the first-ever top-flight meetings between the sides last season, Chaves won 3-1 here, and after finding a new lease of life under Moreno, they could well repeat the feat.
Gil Vicente have been free-scoring, but despite scoring 16 goals in their first seven games, they have still lost four times, including in all three away games so far.
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Braga vs. Rio Ave (Saturday, 6.00pm)
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Braga return to league action after a whirlwind night in Berlin on Tuesday when they face Rio Ave on Saturday evening.
Artur Jorge's side completed a remarkable turnaround against Union Berlin to record their first win in this season's Champions League group stage.
We say: Braga 3-0 Rio Ave
Braga are playing with much more confidence again despite an under-par opening half-hour against Union Berlin in midweek.
The fight they showed to come back and win suggests Braga's season is well and truly off and running, and they should have no problem in beating a Rio Ave side hopelessly out of form.
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Estoril vs. Benfica (Saturday, 8.30pm)
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Benfica make the short trip just outside Lisbon to face Estoril Praia in the Primeira Liga on Saturday night.
After another defeat in Europe this week, Roger Schmidt will hope his side can maintain their fine run of wins domestically before the international break.
We say: Estoril Praia 1-4 Benfica
Benfica have been ruthless in the league since losing to Boavista on the opening day and should have too much for their hosts here.
Estoril have been in fine goalscoring form all season but simply concede too many goals, and Benfica will expect to take advantage of that in this one.