Cambridge vs. Peterborough (Saturday, 12.00pm)
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Aiming to arrest a concerning slump in their form and maintain their standing in the top six of the League One table, Peterborough United will make the short trip to take on rivals Cambridge United at the Abbey Stadium on Saturday.
The visitors have fallen behind in the race for promotion following four straight defeats in England's third tier, while their hosts dropped to 17th spot after a loss of their own last weekend and will begin life without manager Neil Harris.
We say: Cambridge United 1-3 Peterborough United
Peterborough United's recent league form is certainly concerning, but they possess the quality to bounce back to winning ways in style, particularly on the back of a confidence-boosting midweek win to book a trip to Wembley.
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Barnsley vs. Derby (Saturday, 3.00pm)
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A crucial game at the top end of the League One table will take place at Oakwell on Saturday, as Barnsley entertain Derby County.
Both in the midst of unbeaten streaks, the visitors sit second in England's third tier, six points ahead of their hosts who have a game in hand.
We say: Barnsley 1-1 Derby County
With both sides boasting plenty of quality throughout their ranks, we anticipate a tight and cagey encounter at Oakwell on Saturday given the high stakes.
We cannot quite pick a winner between two in-form teams and instead anticipate a share of the spoils in South Yorkshire.
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Blackpool vs. Bolton (Saturday, 3.00pm)
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Blackpool will look to bounce back from a defeat in the EFL Trophy semi-finals when they play host to Bolton Wanderers in Saturday's League One contest.
Meanwhile, promotion-chasing Bolton Wanderers will have the chance to record a second straight victory after beating Cambridge United in midweek.
We say: Blackpool 1-1 Bolton Wanderers
Bolton will be determined to claim three points to help in the promotion push, but as they have gone over 46 years without a competitive away win over Blackpool, we think that the visitors will have to settle for a share of the spoils on Saturday.
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Bristol Rovers vs. Carlisle (Saturday, 3.00pm)
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Bristol Rovers will be expecting to bounce back from defeat when they host Carlisle United in League One on Saturday.
The visitors are marooned to the bottom of the table, having lost seven league games in a row.
We say: Bristol Rovers 3-1 Carlisle United
Having lost seven of their last 10 matches, Bristol Rovers will be relishing facing the worst team in the division on recent form. We can envisage them cutting loose with a few goals and a comfortable victory.
Carlisle have lost seven successive games and appear doomed for an instant return to League Two, but they are likely to stick with club legend Simpson after defying the odds to reach this level of the footballing pyramid in the first place.
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Burton Albion vs. Northampton (Saturday, 3.00pm)
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Both aiming to extend pleasing runs of results in recent weeks, Burton Albion and Northampton Town will square off at the Pirelli Stadium on Saturday.
The hosts have moved six points clear of the relegation zone in the League One table with back-to-back wins, while their visitors sit 11th following a victory a draw in their last two outings.
We say: Burton Albion 1-1 Northampton Town
Both teams will head into Saturday's game with renewed confidence thanks to recent results, and while the visitors have enjoyed the better campaign and boast the stronger squad, Burton Albion are certainly improving and should have enough to earn a share of the points on home turf.
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Charlton vs. Portsmouth (Saturday, 3.00pm)
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Charlton Athletic will look to end a 15-game winless league run when they welcome Portsmouth to The Valley on Sunday.
Meanwhile, League One leaders Portsmouth will be hoping to continue their fine run of form, having won each of their last four matches.
We say: Charlton Athletic 2-2 Portsmouth
Portsmouth may currently be enjoying a fine run of form, but they have failed to win any of their last five meetings with Saturday's opponents.
With that in mind, we think that the leaders will have to settle for a point against a Charlton side that has drawn their last two matches.
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Exeter vs. Fleetwood (Saturday, 3.00pm)
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Both sides will be aiming to bounce back from defeat when Exeter City host Fleetwood Town in League One on Saturday.
Exeter were beaten 1-0 away to Lincoln City last time out, while Fleetwood lost 2-1 at home to Barnsley.
We say: Exeter City 2-1 Fleetwood Town
Exeter should have enough points on the board to avoid serious danger, and they will be viewing this game as a perfect opportunity to return to winning ways and cement their status in League One.
Fleetwood, on the other hand, need every point that they can grab in their current predicament. We expect to see a closely-fought game which could go either way, but we will go with the home side to narrowly edge it.
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Oxford Utd vs. Leyton Orient (Saturday, 3.00pm)
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Oxford United will be aiming to extend their unbeaten run to seven league games when they host Leyton Orient in League One on Saturday.
The visitors, meanwhile, suffered a disappointing 2-1 defeat at home to Burton Albion last time out to lose ground on the playoff spots.
We say: Oxford United 1-1 Leyton Orient
Although Oxford have proven tough to beat in recent weeks, they are also finding it difficult to win matches. Leyton Orient are still pushing to finish inside the top six, even if their chances appear slim after losing to Burton last weekend.
Oxford should have enough quality to maintain their unbeaten run, but we think that they may have to settle for a point once again, potentially allowing the likes of Stevenage and Blackpool to close the gap on them.
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Port Vale vs. Lincoln (Saturday, 3.00pm)
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Lincoln City will attempt to extend their unbeaten run to seven matches when they travel to Vale Park for Saturday's League One meeting with Port Vale.
The Valiants, meanwhile, will be desperate to claim all three points after failing to win any of their last eight matches.
We say: Port Vale 1-1 Lincoln City
Port Vale will be looking to end their poor run of form, but we think they will have to settle for a point, especially as Lincoln have avoided defeat in each of their last seven league matches.
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Reading vs. Shrewsbury (Saturday, 3.00pm)
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Reading will have the chance to record a second straight victory when they welcome Shrewsbury Town to the Select Car Leasing Stadium on Saturday.
The visitors, who occupy 19th place in the League One table, will be desperate to bring an end to their four-game winless run.
We say: Reading 3-1 Shrewsbury Town
With Shrewsbury currently experiencing a poor run of form, we think Reading will showcase their strength on home turf to claim all three points and extend their unbeaten home run to eight matches.
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Stevenage vs. Wycombe (Saturday, 3.00pm)
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Stevenage will be hoping to bounce back from successive defeats when they host Wycombe Wanderers in League One on Saturday.
The visitors, meanwhile, are also winless in their last two games but have generally improved of late.
We say: Stevenage 1-0 Wycombe Wanderers
Stevenage should be fresher having had a free midweek, whereas Wycombe were involved in the EFL Trophy on Wednesday. The hosts will be determined to return to winning ways after enduring some tough results of late.
We can envisage a match low on chances, with both teams involved in tight games last weekend. In the end, we expect Stevenage to grind out a victory and boost their playoff hopes in the process.