The 27-year-old, who has now been released back to his club, is reported to have suffered a 'slight hamstring injury' during a training session on Sunday evening.
Silva had been pencilled in for an appearance in Tuesday's friendly against Chile, but the Spanish Football Federation have confirmed his absence.
Real Madrid midfielder Isco has also been forced to withdraw from the squad.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Liverpool | 10 | 8 | 1 | 1 | 19 | 6 | 13 | 25 |
| 2 | Manchester CityMan City | 10 | 7 | 2 | 1 | 21 | 11 | 10 | 23 |
| 3 | Nottingham ForestNott'm Forest | 10 | 5 | 4 | 1 | 14 | 7 | 7 | 19 |
| 4 | Chelsea | 10 | 5 | 3 | 2 | 20 | 12 | 8 | 18 |
| 5 | Arsenal | 10 | 5 | 3 | 2 | 17 | 11 | 6 | 18 |
| 6 | Aston Villa | 10 | 5 | 3 | 2 | 17 | 15 | 2 | 18 |
| 7 | Tottenham HotspurSpurs | 10 | 5 | 1 | 4 | 22 | 11 | 11 | 16 |
| 8 | Brighton & Hove AlbionBrighton | 10 | 4 | 4 | 2 | 17 | 14 | 3 | 16 |
| 9 | Fulham | 10 | 4 | 3 | 3 | 14 | 13 | 1 | 15 |
| 10 | Bournemouth | 10 | 4 | 3 | 3 | 13 | 12 | 1 | 15 |
| 11 | Newcastle UnitedNewcastle | 10 | 4 | 3 | 3 | 10 | 10 | 0 | 15 |
| 12 | Brentford | 10 | 4 | 1 | 5 | 19 | 20 | -1 | 13 |
| 13 | Manchester UnitedMan Utd | 10 | 3 | 3 | 4 | 9 | 12 | -3 | 12 |
| 14 | West Ham UnitedWest Ham | 10 | 3 | 2 | 5 | 13 | 19 | -6 | 11 |
| 15 | Leicester CityLeicester | 10 | 2 | 4 | 4 | 14 | 18 | -4 | 10 |
| 16 | Everton | 10 | 2 | 3 | 5 | 10 | 17 | -7 | 9 |
| 17 | Crystal Palace | 10 | 1 | 4 | 5 | 8 | 13 | -5 | 7 |
| 18 | Ipswich TownIpswich | 10 | 0 | 5 | 5 | 10 | 21 | -11 | 5 |
| 19 | Southampton | 10 | 1 | 1 | 8 | 7 | 19 | -12 | 4 |
| 20 | Wolverhampton WanderersWolves | 10 | 0 | 3 | 7 | 14 | 27 | -13 | 3 |
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