With Manchester City not in Premier League action this weekend there could be another shift in power in the title race as Liverpool and Tottenham do play.
Liverpool head to Manchester United in one of the division's heavyweight clashes while there are also several important games at the foot of the table.
Here, Press Association Sport looks at five talking points ahead of the action.
Can Spurs prove they are the real deal?
"We need to assess them in one more training session, but they are doing well."
⏱️ 🗣️ Mauricio provides an update on @HKane and @Ben_Davies33 and looks ahead to Burnley. #COYS pic.twitter.com/GvACk615de
— Tottenham Hotspur (@SpursOfficial) February 21, 2019
Harry Kane's return from an ankle injury could not be better timed as he is back for Tottenham's lunchtime game at Burnley, where Spurs could steal a march in the title race. With Manchester City not in action due to the Carabao Cup final with Chelsea and Liverpool not playing until Sunday afternoon, Mauricio Pochettino's men, currently in third, will cut the gap on those two to just two points if they can win in Lancashire. Much of the title race talk has only involved City and Liverpool, but if Spurs win and Jurgen Klopp's side lose at Old Trafford, winning the title will be in their own hands, with visits to Anfield and the Etihad Stadium to come.
Can United dent Liverpool's title bid?
Despite Jose Mourinho's attempts to make recent games between the two sides dull as dishwater, the United-Liverpool clash remains one of the most highly-anticipated of the season. And Sunday's meeting at Old Trafford has a different dynamic, following the resurgence of United under Ole Gunnar Solskjaer and Liverpool's title pursuit. This represents a much sterner test for Jurgen Klopp's side than it might have previously and Solskjaer may well take extra pleasure in strengthening his hopes of landing the Old Trafford job permanently by denting their greatest rivals' title ambitions. The Norwegian, who scored three goals against the Reds as a player, has led United back into the top four and will be keen to consolidate that position.
Friday night lights in relegation battle
Claudio senses there is plenty of fight left in his players: https://t.co/CFxg0XtEDF #WHUFUL #COYW pic.twitter.com/DScwpC4apK
— Fulham Football Club (@FulhamFC) February 21, 2019
Both Cardiff and Fulham could boost their differing chances of beating the drop as they are both in action on Friday night. The Bluebirds, currently in 17th, could climb as high as 13th with a win over Watford at home and that will provide further solace to the unsavoury manner in which the fall-out of Emiliano Sala's death – and disputes over his transfer fee and contract – have been played out in the public domain. Fulham's plight is far worse than Cardiff's and there is a sense of now-or-never as they head across the capital to West Ham, hoping for a first away win of the season. The Cottagers, who have lost five of their last six games, are eight points behind Neil Warnock's side and surely must start winning soon if they are to avoid an instant return to the Championship.
Pressure building on Claude Puel?
With no wins in six, which included an FA Cup embarrassment at Newport, the pressure is mounting on Leicester boss Claude Puel, who is also having to fight fires within his own dressing room. There were rumours of a bust-up with Jamie Vardy ahead of the 3-1 defeat to Tottenham earlier this month, while the Frenchman has had to hold clear-the-air with Kasper Schmeichel after the goalkeeper's father Peter criticised Puel's management style. A home game with Crystal Palace represents a chance to end the poor run, but could also provide another problem if they were to get beaten.
Can Arsenal continue to dominate Southampton?
The race for the final top four spot looks like coming down to one of Manchester United, Arsenal and Chelsea and the Gunners could enhance their chances with a home game against Southampton, who occupy the bottom three. Arsenal were in Europa League action on Thursday night but will hope to take advantage of Chelsea not featuring in the league this weekend and a potentially tricky home game for United against Liverpool. The Saints could do with upsetting the odds as they remain entrenched in relegation danger and if they were to win it would be a big surprise. Arsenal is a ground Southampton simply do not win at, in fact you have to go back to 1987 for the last time they triumphed at the home of the Gunners in the Premier League.
ga('create', 'UA-72310761-1', 'auto', {'name': 'pacontentapi'});
ga('pacontentapi.set', 'referrer', location.origin);
ga('pacontentapi.set', 'dimension1', 'By Jonathan Veal, Press Association Sport');
ga('pacontentapi.set', 'dimension2', '6adf6a5d-569e-4e36-a3cf-6286bd78e06e');
ga('pacontentapi.set', 'dimension3', 'paservice:sport,paservice:sport:football,paservice:sport:uk,paservice:sport:world');
ga('pacontentapi.set', 'dimension6', 'story');
ga('pacontentapi.set', 'dimension7', 'composite');
ga('pacontentapi.set', 'dimension8', null);
ga('pacontentapi.set', 'dimension9', 'sport:football');
ga('pacontentapi.send', 'pageview', { 'location': location.href, 'page': (location.pathname + location.search + location.hash), 'title': 'Five talking points ahead of this weekend\u2019s games in the Premier League'});
