Diego Alonso will attempt to claim his first victory as Sevilla boss when his side face Quintanar in the first round of the Copa del Rey on Wednesday.
The hosts, who play their league football in the sixth tier, are set to compete in the main draw of the Copa del Rey for the first time in their history.
Match preview
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Quintanar are looking forward to a memorable clash against the Europa League winners after they secured their place in the main draw with a preliminary-round victory over Club Union Zona Norte.
Joselu's 13th-minute strike proved to be the only goal of the game, sealing Quintanar's spot in the first round of the Copa del Rey for the very first time.
Wednesday's hosts have made a steady start to their league campaign in the Primera Autonomica Preferente, having picked up 14 from eight matches.
Quintanar have avoided defeat in all five of their home games this season, but they will have to pull off an almighty cup upset if they are to maintain their unbeaten home record.
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Wednesday's contest may take place at the start of November, but Sevilla have already changed their manager this season after Jose Luis Mendilibar was dismissed following a 2-2 draw with Rayo Vallecano.
Mendilibar, who led Sevilla to their seventh Europa League title, experienced a difficult start to the season after seeing his side win just two of their opening 11 competitive games.
The Sevilla hierarchy opted to replace Mendilibar with former Uruguay boss Alonso, who has failed to win any of his first three games as manager (D1, L2).
Alonso began his tenure with a 1-1 draw against Real Madrid and a 2-1 Champions League defeat to Arsenal, before Sevilla fought back from two goals down to draw 2-2 with fellow Andalusian side Cadiz thanks to goals from Lucas Ocampos and Ivan Rakitic.
Having failed to win any of their last six matches in all competitions, Sevilla have been presented with a golden opportunity to return to winning ways against sixth-tier Quintanar.
The visitors have won the Copa del Rey on five occasions, and they will hope that this is the start of a memorable cup run, as they look to lift the cup for the first time since the 2009-10 season.
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Team News
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Quintanar are unable to call upon the suspended Mario Camacho, who received a red card in the victory over Club Union Zona Norte.
After scoring the winning goal in the previous round, Joselu will be dreaming of finding the net against La Liga opposition.
As for the visitors, Marcao is expected to miss out through injury, while Jesus Navas is unlikely to feature after missing training on Monday.
The likes of Sergio Ramos, Suso, Rakitic and Ocamposare not expected to feature in the lineup, with Alonso expected to give his fringe players a chance.
Marko Dmitrovic, Adria Pedrosa, Kike Salas and Oliver Torres and Rafa Mir are among those that could be included in Wednesday's starting XI.
Quintanar possible starting lineup:
Moreno; Barrios, Gracia, Navalon, Jimenez; Joselu, Garcia, Heras, Banbe, Minos; Contento
Sevilla possible starting lineup:
Dmitrovic; Sanchez, Salas, Nianzou, Pedro; Fernando, Jordan; Lamela, Torres, Lukebakio; Mir
We say: Quintanar 0-4 Sevilla
Wednesday will be a momentous occasion for sixth-tier Quintanar, but Sevilla will be in no mood to join in the festivities.
Although they are likely to be a much-changed side, we still expect the visitors to cruise to a comfortable victory over their hosts.
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