The Belgian international suffered the problem during the club's 3-1 defeat to Sunderland in the Asia Cup.
Manager Andre Villas-Boas told reporters: "Jan has had damage to his ligaments, and he is most likely to be out of training for around two to three weeks."
Vertonghen made 48 appearances during his debut season at White Hart Lane.
Restore Data
| Team | P | W | D | L | F | A | GD | PTS | |
| 1 | Manchester CityMan City | 4 | 4 | 0 | 0 | 11 | 3 | 8 | 12 |
| 2 | Arsenal | 4 | 3 | 1 | 0 | 6 | 1 | 5 | 10 |
| 3 | Newcastle UnitedNewcastle | 4 | 3 | 1 | 0 | 6 | 3 | 3 | 10 |
| 4 | Liverpool | 4 | 3 | 0 | 1 | 7 | 1 | 6 | 9 |
| 5 | Aston Villa | 4 | 3 | 0 | 1 | 7 | 6 | 1 | 9 |
| 6 | Brighton & Hove AlbionBrighton | 4 | 2 | 2 | 0 | 6 | 2 | 4 | 8 |
| 7 | Nottingham ForestNott'm Forest | 4 | 2 | 2 | 0 | 4 | 2 | 2 | 8 |
| 8 | Chelsea | 4 | 2 | 1 | 1 | 8 | 5 | 3 | 7 |
| 9 | Brentford | 4 | 2 | 0 | 2 | 6 | 6 | 0 | 6 |
| 10 | Manchester UnitedMan Utd | 4 | 2 | 0 | 2 | 5 | 5 | 0 | 6 |
| 11 | Bournemouth | 4 | 1 | 2 | 1 | 5 | 5 | 0 | 5 |
| 12 | Fulham | 4 | 1 | 2 | 1 | 4 | 4 | 0 | 5 |
| 13 | Tottenham HotspurSpurs | 4 | 1 | 1 | 2 | 6 | 4 | 2 | 4 |
| 14 | West Ham UnitedWest Ham | 4 | 1 | 1 | 2 | 5 | 6 | -1 | 4 |
| 15 | Leicester CityLeicester | 4 | 0 | 2 | 2 | 5 | 7 | -2 | 2 |
| 16 | Crystal Palace | 4 | 0 | 2 | 2 | 4 | 7 | -3 | 2 |
| 17 | Ipswich TownIpswich | 4 | 0 | 2 | 2 | 2 | 7 | -5 | 2 |
| 18 | Wolverhampton WanderersWolves | 4 | 0 | 1 | 3 | 4 | 11 | -7 | 1 |
| 19 | Southampton | 4 | 0 | 0 | 4 | 1 | 8 | -7 | 0 |
| 20 | Everton | 4 | 0 | 0 | 4 | 4 | 13 | -9 | 0 |
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