Guimaraes vs. Moreirense (Saturday, 3.30pm)
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Vitoria de Guimaraes will be looking to move level with Braga in the Conference League qualification spot when they go head-to-head with Moreirense on Saturday.
Os Verdes e Brancos have failed to win their last 10 visits to the Estadio Dom Afonso Henriques since February 2013 and will head into the weekend seeking to end this poor run.
We say: Vitoria de Guimaraes 2-1 Moreirense
With just eight games to go, Vitoria de Guimaraes know they cannot afford any slip-ups if they are to secure a top-four finish. Pacheco's men have hit their stride in recent weeks, and we fancy them to come away with all three points in front of their home supporters.
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Arouca vs. Farense (Saturday, 3.30pm)
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Relegation-threatened SC Farense travel to the Estadio Municipal de Arouca on Saturday afternoon as they face up against top-half Arouca.
The visitors sit in 11th place, but just four points above Portimonense in the relegation playoff spot, while the hosts are seven points better off than the visitors and sit in seventh place.
We say: Arouca 3-1 SC Farense
The return of talisman Mujica will give the home side a huge boost for this game, especially if the striker returns in the same vein of form that saw him score eight in eight games before his injury.
The visitors have struggled for victories in recent weeks and have only managed three away victories across the entire season, and we expect them to fail in their search for victory in this one.
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Boavista vs. Rio Ave (Saturday, 6.00pm)
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Two sides looking to avoid relegation from the Primeira Liga come together on Saturday evening when Boavista host Rio Ave at the Estadio do Bessa Seculo XXI.
The hosts are 10th coming into this game, but just five points above Portimonense who occupy the relegation playoff spot, while the visitors are in 15th and just two points clear of the drop zone.
We say: Boavista 0-1 Rio Ave
The hosts will have multiple players missing or not fully fit from their backline for this game, giving Rio Ave a big chance to grab their first away win of the season.
The visitors have improved in recent games, albeit failing to win in any of their last five, with valuable draws against Sporting and Braga, leading us to believe they will come out victorious.
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Estoril vs. Porto (Saturday, 8.30pm)
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Two sides who could do well with all three points go head-to-head in round 27 of the Primeira Liga as Estoril Praia play host to Porto at the Estadio Antonio Coimbra da Mota on Saturday.
While the Canarinhos will be seeking to pull five clear of the relegation zone, Porto will be looking to make it three league wins on the bounce and move within three points of the Champions League qualifying places.
We say: Estoril Praia 1-3 Porto
Given the stakes of this weekend's clash for both sides, we anticipate a thrilling contest at the Estadio Antonio Coimbra da Mota. However, Porto boast the firepower needed to get this one over the line, and we fancy them to extend their dominance over the Canarinhos.