Leicester Tigers director of rugby Richard Cockerill has revealed that Manu Tuilagi will be sidelined for "a few weeks" with a groin injury.
The England centre suffered the problem on Saturday during his club's win over Ulster in the European Rugby Champions Cup.
Tuilagi recently returned to action after spending three weeks out with a similar injury.
Leicester are yet to confirm the severity of the strain, but Cockerill believes that the 23-year-old will miss England's upcoming autumn internationals.
England are next in action on November 8 when they welcome world champions New Zealand to Twickenham.