Barcelona boss Luis Enrique has decided to rest several of the players who contributed to his side's 2-0 victory at Arsenal in the Champions League.
As expected, Claudio Bravo returns in goal, while there are also starts for Aleix Vidal, Jeremy Mathieu, Sergi Roberto and Arda Turan.
Javier Mascherano and Andres Iniesta are among the players to drop to the bench, but Lionel Messi has been named in attack alongside usual strike partners Neymar and Luis Suarez.
Sevilla coach Unai Emery has also made alterations, with as many as nine changes being made after their Europa League fixture on Thursday night.
Only Timothee Kolodziejczak and Vicente Iborra remain in the side as Sevilla look to move into fifth place ahead of Celta Vigo.
Barcelona: Bravo, Pique, Busquets, Arda, Suarez, Messi, Neymar, Alba, Sergio Roberto, Aleix Vidal, Mathieu
Subs: Ter Stegen, Rakitic, Alves, Iniesta, Mascherano, Bartra and Munir
Sevilla: Sergio Rico, Coke, Rami, Kolo, Tremoulinas, Cristoforo, N'Zonzi, Vitolo, Iborra, Krohn-Dehli, Gameiro
Keep up to date with the match at Camp Nou with Sports Mole's live text commentary.
Darren Plant
