Bayern vs. Augsburg (Saturday, 2.30pm)
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Bayern Munich will be aiming to remain at the top of the Bundesliga table when they host Augsburg at the Allianz Arena on Saturday.
The visitors, meanwhile, could move 11 points clear of the relegation zone if they can spring a huge upset.
We say: Bayern Munich 3-0 Augsburg
We expect Bayern to cruise to a comfortable victory against one of their local rivals Augsburg, whose away form has been wretched for most of the current campaign.
However, with this being the reigning champions' third match within six days, Nagelsmann may ask his players to take their foot off the gas ahead of travelling to Bayer Leverkusen next weekend.
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RB Leipzig vs. Borussia M'bach (Saturday, 2.30pm)
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Both sides will be aiming to return to winning ways when RB Leipzig host Borussia Monchengladbach in the Bundesliga on Saturday.
Leipzig's title hopes were significantly damaged by a 2-1 defeat to Borussia Dortmund last Friday, while Gladbach fell back into the bottom half of the table after being held by Freiburg at home.
We say: RB Leipzig 2-1 Borussia Monchengladbach
Despite missing several influential players through injury, Leipzig should be able to get themselves back on track with a victory on home territory this weekend.
Gladbach have won just once on the road all season in the Bundesliga, so it would be a major surprise if they came away from the Red Bull Arena with all three points, even if they are likely to have threatening moments in transition.
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Frankfurt vs. Stuttgart (Saturday, 2.30pm)
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The 100th Bundesliga meeting between Eintracht Frankfurt and Stuttgart takes place at the Deutsche Bank Park on Saturday afternoon.
While the hosts are seeking to claim their fifth successive home victory in the top flight, the visitors are still searching for their first away league win of the season.
We say: Eintracht Frankfurt 2-1 Stuttgart
While Frankfurt are sure to have one eye on next week's Champions League clash with Napoli, they can ill-afford to drop more points in the Bundesliga if they wish to qualify for Europe's premier club competition this term.
Stuttgart, meanwhile, are desperate to claim maximum points in their quest to move away from the relegation zone, but we believe that the hosts will edge a closely-fought contest at the Deutsche Bank Park.
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Hertha Berlin vs. Mainz (Saturday, 2.30pm)
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Mainz 05 will go in search of a fifth successive Bundesliga victory when they travel to the German capital to face Hertha Berlin at the Olympiastadion on Saturday afternoon.
Having lost 10 of their last 14 league matches, Hertha find themselves one point clear of the relegation zone and 15 points shy of seventh-placed Mainz.
We say: Hertha Berlin 0-2 Mainz 05
In addition to winning each of their last four league games – and five of their previous six – Mainz head into Saturday's showdown on the back of successive clean sheets.
With that in mind, we expect the 05ers to extend their winning streak to five matches with a third consecutive clean-sheet victory, piling more pressure on relegation-threatened Hertha.
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Schalke vs. Dortmund (Saturday, 5.30pm)
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The 100th Bundesliga meeting between Borussia Dortmund and regional rivals Schalke 04 takes centre stage on Saturday evening, as they meet at the Veltins-Arena.
Continuing a conflict dating back to 1925, the latest Revierderby pits together a home side scrapping for survival with visitors who have ambitions of beating Bayern Munich to the title.
We say: Schalke 04 1-2 Borussia Dortmund
While they have improved dramatically in recent weeks, Schalke's mettle will truly be tested by fired-up local rivals aiming for the title. Dortmund's disappointment at exiting Europe will quickly dim, and with so much at stake they can produce at least a couple of goals and another Revierderby victory.