Lyon will bid to extend their unbeaten league run to five matches when they travel to Stade Francis-Le Ble to face Brest on Wednesday.
The hosts, on the other hand, have struggled for wins of late, with just one of their last five matches ending in victory.
Match preview
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After finishing just a point clear of the relegation playoff place last season, Brest can be pleased with their efforts in the current campaign.
With six games left to play in Ligue 1, Wednesday's hosts occupy 12th position, with 10 points separating them from the bottom three.
Although their place in the top flight looks to be all but secured, Michel Der Zakarian will be challenging his side to end the season in style, but to do that, they must end a winless three-game home run.
Brest's recent form has been mixed, with their last six matches resulting in three defeats, two wins and a draw, while their last outing saw St Etienne claim all three points despite Der Zakarian's side taking the lead in that contest.
Franck Honorat gave Les Pirates an early lead, but a brace from Mahdi Camara turned the game on its head before the break and with no goals forthcoming in the second half, Brest slumped to a 2-1 defeat, ensuring that they head into Wednesday's encounter in a downbeat mood.
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The visitors, meanwhile, lifted their spirits following their Europa League exit by thrashing Bordeaux 6-1 on Sunday.
Peter Bosz's charges ran riot at the Parc Olympique Lyonnais, with Moussa Dembele and Karl Toko Ekambi netting braces, while Lucas Paqueta and former Brest player Romain Faivre also put their names on the scoresheet in the comprehensive victory.
It was a result that was much needed after Les Gones were dumped out of the Europa League by West Ham United last Thursday, and the win was also crucial as it extended their Ligue 1 unbeaten run to four matches.
As the season heads into the final straight, Lyon have their eyes firmly set on a European place, with Wednesday's visitors currently four points adrift of the top five.
Despite enjoying a promising run in the league, Les Gones have struggled for victories on the road this season, winning just four of their 15 away league games, which will concern Bosz ahead of the midweek contest.
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Team News
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Jeremy Le Douaron will miss out for the hosts due to a groin injury, while Sebastien Cibois is also sidelined with an Achilles tendon injury preventing him from taking part in Wednesday's contest.
Meanwhile, Martin Satriano is set to return to the forward line after serving a one-match suspension, and he will be partnered up front by Honorat, who took his tally for the Ligue 1 season to 11 with his strike on Saturday.
Brest may have to reshuffle the backline, with Christophe Herelle suspended, while Brendan Chardonnet was forced off in the first half against St Etienne, which could present Lilian Brassier and Jere Uronen with starting opportunities.
As for Lyon, Tino Kadewere remains a concern after illness kept the forward out of Sunday's contest, while Rayan Cherki and Sinaly Diomande are long-term absentees.
Bosz also has to cope without Maxence Caqueret and Tanguy Ndombele, who are sidelined due to knee and calf injuries respectively.
Julian Pollersbeck will keep his place in goal, with a thigh problem continuing to keep regular goalkeeper Anthony Lopes out of action.
Brest possible starting lineup:
Bizot; Pierre-Gabriel, Brassier, Duverne, Uronen; Del Castillo, Agoume, Belkebla, Belaili; Honorat, Satriano
Lyon possible starting lineup:
Pollersbeck; Gusto, Da Silva, Lukeba, Henrique; Faivre, Mendes, Paquet; Tete, Toto Ekambi, Dembele
We say: Brest 1-1 Lyon
Lyon have struggled for victories on their travels in Ligue 1 this season, and with their last three away matches in all competitions ending in draws, we think that the visitors will be held to a point by Brest on Wednesday.
Top tip
Data Analysis
Our analysis of all available data, including recent performances and player stats up until an hour before kickoff, suggested the most likely outcome of this match was a Lyon win with a probability of 56.4%. A draw had a probability of 22.2% and a win for Brest had a probability of 21.38%.
The most likely scoreline for a Lyon win was 1-2 with a probability of 9.9%. The next most likely scorelines for that outcome were 0-1 (9.56%) and 0-2 (9.1%). The likeliest drawn scoreline was 1-1 (10.39%), while for a Brest win it was 2-1 (5.66%). The actual scoreline of 2-1 was predicted with a 5.7% likelihood.
