Tottenham Hotspur will be forced to cope without Son Heung-min for the second leg of their EFL Cup semi-final with Chelsea on Wednesday night.
The South Korea international reported pain in his leg following the 2-0 defeat at Stamford Bridge last week, and there are now fears that he could be absent until after the next international break.
Antonio Conte is also without Cristian Romero for the time being - although the Argentine is edging closer to a return - while Eric Dier and Steven Bergwijn are also absent.
Multiple changes will be in the offing from the FA Cup victory over Morecambe, starting with Pierluigi Gollini handing the gloves back over to Hugo Lloris.
Japhet Tanganga should take advantage of Dier's absence alongside Davinson Sanchez and Ben Davies, with Joe Rodon set to cede his place in the starting lineup.
The less said about Tanguy Ndombele's performance at the weekend the better, as the Frenchman prepares to make way for Pierre-Emile Hojbjerg, but Oliver Skipp will not easily displace Harry Winks.
With no Son available to Conte, the ex-Chelsea boss must decide whether to hand Dele Alli or Bryan Gil another opportunity in the final third or switch to a 3-5-2, with Winks potentially earning another start in the middle.
Tottenham possible starting lineup: Lloris; Tanganga, Sanchez, Davies; Emerson, Hojbjerg, Skipp, Winks, Reguilon; Lucas, Kane
> Click here to see how Chelsea could line up for this clash
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