RB Leipzig vs. Man City (Wednesday, 8.00pm)
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Manchester City kick-start their Champions League knockout campaign with a trip to Germany where they will face RB Leipzig in the first leg of their last-16 tie on Wednesday night.
The Citizens will be seeking revenge at the Red Bull Arena after losing their previous visit 2-1 in the group stage of last season's competition.
We say: RB Leipzig 1-2 Manchester City
Excluding the away triumph over Arsenal, Man City have been far from their best on the road in recent weeks, and another challenging encounter could be in store on Wednesday as Leipzig have previously shown their threat going forward against the Citizens.
However, City tend to respond well from disappointing results and we expect Guardiola's key men to make the difference in a closely-fought contest in Germany.
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> How Man City could line up against RB Leipzig
> How RB Leipzig could line up against Man City
> Man City injury, suspension list vs. RB Leipzig
> Champions League: RB Leipzig vs. Man City head-to-head record
Inter Milan vs. Porto (Wednesday, 8.00pm)
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The bright lights of the Champions League will shine on San Siro for the second week running on Wednesday night, as Inter Milan host Porto in the first leg of their last-16 tie.
Simone Inzaghi's men finished second in Group C to set up a tie with the Portuguese champions, who took advantage of their adversaries' slip-ups to finish first in Group B.
We say: Inter Milan 1-0 Porto
Pitting two of Europe's tightest rearguards against one another should inevitably lead to a closely-contested affair, and Porto have overcome adversity with vigour during their injury crisis.
However, Conceicao's growing fitness concerns may ultimately count against him at the San Siro fortress, where Inzaghi's side can break down the staunch Dragons backline and end their visitors' unbeaten streak to take a slender advantage to Portugal for the second leg.
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