Manchester City boss Pep Guardiola will have no choice but to wield the axe on young defender Abdukodir Khusanov for Wednesday's Champions League clash with Club Brugge.
The Citizens - who need to win to progress to the playoffs - come into their final league phase battle on the back of a 3-1 Premier League win over Chelsea, where Khusanov made his first start following his January arrival from Lens.
However, the Uzbekistan international was at fault for Noni Madueke's opener just three minutes in and was taken off early in the second half for John Stones, but he was given a rousing reception from the Etihad faithful as he was withdrawn.
Khusanov is now guaranteed to miss out on Wednesday due to ineligibility, as is Vitor Reis, so John Stones should be restored to the XI while Ruben Dias and Nathan Ake recuperate from injuries.
Matheus Nunes has been filling in at right-back since Kyle Walker's move to AC Milan, but a fresh-legged Rico Lewis could now be given another opportunity to impress as Guardiola shuffles the pack.
Rotation could extend to midfield and attack too, as Kevin De Bruyne will no doubt have his eyes on Ilkay Gundogan's spot, while Savinho and Jack Grealish are both contenders to replace the ineligible Omar Marmoush, who was a bright spark on his debut.
The Egypt international is both an option to play alongside and in place of Erling Haaland, but the Scandinavian should reprise his role on Wednesday, where he will look to build on an astonishing record of eight goals from four Champions League games against Belgian clubs.
Manchester City possible starting lineup:
Ederson; Lewis, Stones, Akanji, Gvardiol; Silva, Kovacic; Foden, De Bruyne, Savinho; Haaland