Leicester vs. Chelsea (Saturday, 12.30pm)
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Chelsea will aim to maintain or increase their three-point lead at the top of the Premier League table when they travel to Leicester City for Saturday's early kickoff.
The Blues were held to a 1-1 draw by Burnley last time out, while Brendan Rodgers's side also took a point from their meeting with Leeds United.
We say: Leicester City 0-1 Chelsea
Even if Lukaku is only ready to play 30 or 60 minutes at the King Power, the Belgian's expected return coupled with Mount's re-introduction will hugely benefit Chelsea on the attacking front against a leaky Leicester defence.
The Foxes have been unable to keep the back door shut at home in recent weeks and are still sweating over the fitness of Tielemans, so we expect the Blues to get the job done with professionalism.
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> How Chelsea could line up against Leicester
> Chelsea injury, suspension list vs. Leicester
Aston Villa vs. Brighton (Saturday, 3.00pm)
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The Steven Gerrard era will begin at Aston Villa on Saturday as the out-of-form hosts welcome Brighton & Hove Albion to Villa Park.
Gerrard took over from Dean Smith at the helm during the international break, with Villa having lost their last five Premier League games.
We say: Aston Villa 1-1 Brighton & Hove Albion
Neither of these teams come into this match in particularly good form, although there is no doubt that Brighton have had the better season so far and, given Aston Villa's injuries, perhaps deserve to be regarded as favourites.
However, the arrival of a new boss so often brings with it an immediate boost and, coupled with the international break giving Aston Villa time to shake their five consecutive defeats out of their system, we are backing Gerrard to pick up a point in his first Premier League game as a manager.
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Burnley vs. Crystal Palace (Saturday, 3.00pm)
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Crystal Palace will be bidding to make it three Premier League victories in a row when they travel to Turf Moor on Saturday afternoon to take on Burnley.
The Eagles have overcome Manchester City and Wolverhampton Wanderers in their last two matches to rise into 10th position in the table, while Burnley currently sit 18th, picking up just eight points from 11 games.
We say: Burnley 1-1 Crystal Palace
Both sides will enter this match in good confidence and believing that they are capable of picking up all three points. Palace have been the draw specialists in the league this season, though, sharing the spoils on six occasions, and we are finding it difficult to separate the two sides here.
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Newcastle vs. Brentford (Saturday, 3.00pm)
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Now the only team without a win in the 2021-22 Premier League season, Newcastle United prepare for battle with newly-promoted Brentford at St James' Park on Saturday afternoon in the first game of the Eddie Howe era.
The Magpies rescued a point in a 1-1 draw with Brighton & Hove Albion last time out, while the Bees became the first victims of Norwich City in a 2-1 defeat.
We say: Newcastle United 2-1 Brentford
The new manager bounce should be in full swing for Newcastle in front of a vibrant St James' Park crowd, and they could hardly have been handed a friendlier fixture against a Brentford side devoid of confidence and depleted by injuries.
The Bees have just not been able to find the formula for success against winless sides recently, and we expect the Magpies to finally get off the mark for the season in a dream start for Howe.
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Norwich vs. Southampton (Saturday, 3.00pm)
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Dean Smith will start life in the Norwich City dugout with a home game against Southampton on Saturday, with the Canaries looking to make it back-to-back Premier League victories.
Norwich are still bottom of the table despite beating Brentford before the international break, while Southampton occupy 13th position, picking up 14 points from their opening 11 matches.
We say: Norwich City 1-1 Southampton
Southampton will be eyeing their third Premier League victory in a row, but Norwich should be feeling a lot better about themselves following their first win of the campaign; Smith's arrival will also boost the Canaries, and we can see the two teams playing out a low-scoring draw here.
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Watford vs. Man Utd (Saturday, 3.00pm)
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Manchester United will be bidding to return to winning ways in the Premier League when they make the trip to Vicarage Road on Saturday afternoon to face Watford.
The Red Devils suffered a 2-0 defeat to Manchester City before the international break, while Watford, who are just outside the relegation zone in England's top flight, lost 1-0 at Arsenal in their last contest.
We say: Watford 1-2 Manchester United
Only a win will be good enough for Man United amid a poor run of form, and we are backing the 20-time English champions to triumph here. It is hard to predict a clean sheet for the Red Devils considering their struggles defensively, though, so we have tipped Watford to score in a narrow defeat to Solskjaer's side.
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> How Manchester United could line up against Watford
> Man United injury, suspension list vs. Watford
Wolves vs. West Ham (Saturday, 3.00pm)
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West Ham United will be looking to continue their excellent start to the 2021-22 Premier League season when they head to Molineux on Saturday afternoon to face Wolverhampton Wanderers.
The high-flying Hammers are currently third in the table, three points behind leaders Chelsea, while Wolves occupy eighth position, just one point off sixth-placed Manchester United.
We say: Wolverhampton Wanderers 2-2 West Ham United
West Ham will be bidding to record their fifth league victory in a row this weekend, but Wolves have been impressive in recent weeks, and we are finding it difficult to separate the two sides; it would not be a surprise to see another away victory here, but we have had to settle on an entertaining draw.
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Liverpool vs. Arsenal (Saturday, 5.30pm)
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One of the standout fixtures of the Premier League season will take place on Saturday evening when Liverpool welcome Arsenal to Anfield.
Just one place and two points separate the two sides in the table, with Liverpool sitting fourth and Arsenal fifth after 11 games of the campaign.
We say: Liverpool 3-1 Arsenal
Arsenal fans will not have always been confident travelling to Anfield in recent years given their poor record against the Reds, but this time around they are in fine form and may fancy their chances of picking up a result.
However, this fixture always seems to suit itself well to Klopp's Liverpool, and the league's leading scorers usually help themselves to a few goals against Arsenal too.
The Gunners do have the weapons to hurt a Liverpool defence which looked a little shaky before the international break, but we are backing the hosts to return to winning ways this weekend, particularly as their injury troubles do not look quite as bad as first feared.
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> How Arsenal could line up against Liverpool
> How Liverpool could line up against Arsenal
> Liverpool injury, suspension list vs. Arsenal