England under 21 internationals Danny Welbeck and Tom Cleverley have been handed starting roles by Sir Alex Ferguson for Manchester United's trip to West Bromwich Albion.
Goalkeeper David De Gea and Ashley Young will also make their Premier League debut for the champions.
For hosts West Brom Shane Long has been handed his debut having completed a move from Reading earlier this week, while Ben Foster starts in goal against his former club.
West Brom: Foster; Reid, Tamas, Olsson, Shorey; Brunt, Mulumbu, Scharner, Morrison, Tchoyi; Long.
Man Utd: De Gea; Smalling, Ferdinand, Vidic, Fabio; Young, Anderson, Cleverley, Nani; Rooney, Welbeck.
