Roma manager Rudi Garcia has made three changes to the side that were knocked out of the Coppa Italia by Napoli on Wednesday.
Maicon, Alessandro Florenzi and Vasilis Torosidis replace Michel Bastos, Adem Ljajic and Daniele De Rossi.
Despite their cup defeat, Roma are unbeaten in their last four Serie A games and have lost just once all season.
Sampdoria, meanwhile, welcome Shkodran Mustafi and Pawel Wszolek into the team in place of Stefano Okaka and Michele Fornasier.
Roma: De Sanctis; Maicon, Benatia, Castan, Torosidis; Pjanic, Nainggolan, Strootman; Florenzi, Destro, Gervinho
Sampdoria: Da Costa; De Silvestri, Mustafi, Gastaldello, Regini; Palombo, Krsticic, Gabbiadini, Soriano; Wszolek, Eder
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Benjamin Topliss
