Top-of-the-table Harlequins will welcome back Nick Evans from injury for their Aviva Premiership match against third-placed Gloucester Rugby on Saturday.
Mike Brown and George Robson also start having been released back to the club from England duty, while Sam Smith takes Ugo Monye's place on the wing.
Gloucester have made four changes to the side that beat Leicester Tigers last weekend, including replacing Charlie Sharples, who is away with England, with Shane Monahan.
Sione Kalamafoni is unavailable due to injury, being replaced by Matt Cox on the blindside flank while Dan Murphy and Martyn Thomas also come in.
Harlequins: Brown, Williams, Hopper, Casson, Smith, Evans, Dickson; Lambert, Gray, Johnston, Kohn, Robson, Fa'asavalu, Wallace, Easter
Replacements: Buchanan, Marfo, Collier, Matthews, Guest, Burns, Botica, Stegmann
Gloucester: Thomas, Monahan, Tindall, Twelvetrees, Simpson-Daniel, Burns, Cowan; Murphy, Edmonds, Harden, Savage, James, Cox, Qera, Morgan
Replacements: d'Apice, Wood, Chistolini, Buxton, Evans, Robson, Molenaar, Cook
