Third will host fourth when Harlequins welcome Northampton Saints for the final round of fixtures in this season's Aviva Premiership tomorrow.
The home side have made four changes to the side that beat Worcester Warriors a fortnight ago, but Chris Robshaw misses out with an ankle injury.
Tom Casson comes in at inside centre, while Rob Buchanan starts at hooker and Tom Guest replaces Maurie Fa'asavalu.
Meanwhile, George Pisi and Samu Manoa are among those returning to the starting lineup for the visitors, who beat Sale Sharks last time out.
Both sides have already qualified for the playoffs, but a big victory would give the winner a chance to move above second-placed Leicester Tigers, securing a home fixture in the semi-finals.
Recent form
Harlequins: WLLLWW
Northampton: WWWLWW
Lineups
Harlequins: Brown, Williams, Lowe, Casson, Monye, Evans, Care, Easter, Wallace, Guest, Robson, Kohn, Johnston, Buchanan, Marler
Northampton Foden, K Pisi, G Pisi, Burrell, Elliott, Myler, Dickson, Manoa, Wood, Clark, Day, Lawes, Mujati, Hartley, Tonga'uiha
Sports Mole says: Northampton to clinch a close game
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