Arsene Wenger has picked Alex Iwobi up front for Arsenal as Alexandre Lacazette drops to the bench ahead of Sunday's Premier League clash with Manchester City.
The 21-year-old is joined in attack by Alexis Sanchez, who lines up in the middle, and Mesut Ozil.
The Gunners have reverted to four at the back with Per Mertesacker dropping out through illness.
Francis Coquelin starts in midfield alongside Aaron Ramsey and Granit Xhaka while Sead Kolasinac is fit to line up on the left.
Pep Guardiola, meanwhile, makes two changes from the team which beat Napoli 4-2 in their midweek Champions League encounter.
Captain David Silva and Kyle Walker return in place of Ilkay Gundogan and Danilo.
Sergio Aguero leads the line on his own, with Gabriel Jesus kept in reserve on the bench, while Raheem Sterling is preferred to Bernardo Silva on the wing.
Manchester City: Ederson, Walker, Stones, Otamendi, Delph, Fernandinho, David Silva, Sane, De Bruyne, Sterling, Aguero
Subs: Bravo, Danilo, Gundogan, Mangala, Bernardo Silva, Jesus, Toure
Arsenal: Cech, Bellerin, Monreal, Koscielny, Kolasinac, Coquelin, Xhaka, Ramsey, Ozil, Sanchez, Iwobi
Subs: Macey, Debuchy, Lacazette, Wilshere, Giroud, Walcott, Elneny
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Giuseppe Labellarte
