Ajax play host to FC Utrecht on Thursday evening knowing that victory will put them on the brink of winning the Eredivisie title.
Meanwhile, the visitors, who currently sit in seventh position, realistically require maximum points if they want to remain in the hunt for a Europa League place.
Match preview
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Having been eliminated from the Europa League at the quarter-final stage, Ajax have fallen short in their bid to win the treble this season.
However, defeating Vitesse in the KNVB Beker final at the weekend helped ease that disappointment, putting the club on the brink of sealing a domestic double by the end of the week.
Victories over Utrecht and AZ Alkmaar will confirm their second successive title, reward for already winning 23 of their 28 top-flight fixtures since the start of the 2020-21 campaign.
Erik ten Hag was left disappointed with the level of performances against Heerenveen and RKC Waalwijk, his side only prevailing by one-goal margins.
Nevertheless, Sebastien Haller got back on the goal trail during those fixtures, taking his return to eight goals from 13 appearances since his January move from West Ham United.
From Utrecht's perspective, they will relish the opportunity to record a shock result having recently moved up to seventh position in the table.
Rene Hake will demand more from his players with a top-five finish still a target, but he will acknowledge that his side are heavy underdogs ahead of the game at the Johan Cruyff Arena.
Letting slip an early lead against rivals Feyenoord is likely to prove decisive in the hunt for the Europa League, although Hake's side still have the 4-1 triumph at ADO Den Haag fresh in their memories.
Top goalscorer Sander van de Streek has failed to get on the scoresheet in his last three outings.
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Team News
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Ten Hag may give consideration to resting a number of Ajax players with AZ to come three days later.
Perr Schuurs and David Neres are among the players who could be drafted into the starting lineup, but Daley Blind remains absent through injury.
With his squad well rested after an 11-day break from action, Utrecht boss Hake could stick with the side which started against Feyenoord.
Giovanni Troupee is in contention for a recall, while Eljero Elia was lively during his late appearance as a substitute in the previous fixture.
Ajax possible starting lineup:
Stekelenburg; Rensch, Timber, Schuurs, Tagliafico; Alvarez, Gravenberch; Neres, Klaassen, Tadic; Haller
FC Utrecht possible starting lineup:
Oelschlagel; Avest, Maarel, Janssen, Warmerdam; Overeem, Maher; Kerk, Gustafson, Boussaid; Streek
We say: Ajax 3-0 FC Utrecht
Now left to concentrate on retaining the league title, Ajax have no excuses when it comes to claiming the top-flight crown.
We expect the home side to cruise to victory in this contest, registering a clean sheet in the process.
Top tip
Data Analysis
Our analysis of all available data, including recent performances and player stats up until an hour before kickoff, suggested the most likely outcome of this match was a Ajax win with a probability of 57.85%. A win for FC Utrecht had a probability of 22.12% and a draw had a probability of 20%.
The most likely scoreline for an Ajax win was 2-1 with a probability of 9.42%. The next most likely scorelines for that outcome were 2-0 (7.1%) and 3-1 (7%). The likeliest FC Utrecht win was 1-2 (5.6%), while for a drawn scoreline it was 1-1 (8.45%). The actual scoreline of 1-1 was predicted with an 8.5% likelihood.