Estudiantes vs. Huachipato (Wednesday, 11.00pm)
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Estudiantes will be looking to return to winning ways in the Copa Libertadores when they take on Huachipato at Estadio Jorge Luis Hirschi on Wednesday night.
Owing to the heavy rains that caused two match postponements earlier in the competition, Group C is the only one that will not be decided in this round of matches.
We say: Estudiantes 2-1 Huachipato
While Estudiantes have been a long way from the sort of form we saw last season, they have maintained an impressive record at Estadio Jorge Luis Hirschi this term. The hosts have already beaten The Strongest on home turf in this competition and we feel they will be able to grind out another victory in this one.
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Gremio vs. The Strongest (Wednesday, 11.00pm)
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After a month out, Gremio take the field when the play host to Bolivian outfit The Strongest in the Copa Libertadores on Wednesday night.
With most parts of Rio Grande do Sul still recovering from the recent catastrophic floods, Gremio will play their next four home fixtures at Estadio Couto Pereira in Curitiba.
We say: Gremio 1-1 The Strongest
While Gremio are massive favourites according to the bookmakers, it will be interesting to see how they fare after a full month away from competitive football and playing at a makeshift home ground.
The visitors have been very good in this competition so far, and we feel they may be able to hold their opponents to draw in this one.
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Cerro Porteno vs. Colo-Colo (Thursday, 1.30am)
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The final matchday in the group stage of the Copa Libertadores will see Cerro Porteno and Colo-Colo face off at Estadio Ueno La Nueva Olla on Thursday morning.
Only Fluminense have secured their place in the round of 16 from Group A, while both these sides and bottom-club Alianza Lima are still able to join the Brazilian outfit in the knockout stage.
We say: Cerro Porteno 1-0 Colo-Colo
Both sides come into this match with good recent form, but the hosts have proven very difficult to beat on their home patch of late and are yet to concede at Estadio Ueno La Nueva Olla in this competition.
We are expecting a very evenly contested matchup here and feel that the first goal will likely end up being the winner.
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Fluminense vs. Alianza Lima (Thursday, 1.30am)
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Already into the last 16 of this year's Copa Libertadores, reigning champions Fluminense host Group A's last-placed side Alianza Lima at the Maracana on Wednesday.
Pursuing back-to-back continental crowns, Flu qualified for the knockout stage with a round to spare and can now complete a year without being beaten in South America's top club competition; Alianza, meanwhile, must win to have any hope of going through.
We say: Fluminense 2-0 Alianza Lima
Neither side is in top form on the domestic scene, but Flu's home advantage and long unbeaten record in this competition should see them cruise to victory. Only a point would keep Alianza's continental campaign alive, but they may be staring at a group-stage exit.
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Sao Paulo vs. Talleres (Thursday, 1.30am)
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Sao Paulo and Talleres close out their respective Copa Libertadores group-stage campaigns with a meeting at Estadio Do Morumbi on Thursday.
Having both secured a place in the knockout stages, the two teams now seek to qualify as group winners in what should be an entertaining affair.
We say: Sao Paulo 2-1 Talleres
Both Santos and Talleres have shown they have goals in them, so an open and end to end affair is on the cards here. We can also see the hosts getting the job done, albeit by only a narrow margin.
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Barcelona vs. Cobresal (Thursday, 1.30am)
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Barcelona SC and Cobresal will be looking to wrap up their Copa Libertadores campaigns on a high in Thursday's encounter at Estadio Monumental Banco Pichincha.
Having already been knocked out of South America's premier club competition, both teams will now battle it out for a place in the Copa Sudamericana.
We say: Barcelona SC 3-1 Cobresal
Following a disastrous Copa Libertadores group phase, Barcelona and Cobresal will be keen to put on a show in their final outing and we are expecting an exciting watch. That said, we are also tipping the hosts to emerge triumphant come the end of the 90 minutes.