Inter Milan could make changes to their formation after losing 3-0 at Fiorentina before the international break.
Walter Mazzarri's team have won just twice in six league games this season, already leaving the Nerazzurri 10 points behind leaders Juventus.
With several alterations expected, midfielder Hernanes and attacker Rodrigo Palacio are in contention for starting roles at the San Siro.
After a slow start to the season, Napoli have begun to turn their form around with wins being registered in their last three fixtures.
That has helped Rafael Benitez's side up to seventh in the table, and the Spaniard could opt to name the same team that beat Torino last time out.
Lorenzo Insigne netted the first and assisted the second during that triumph to suggest that he could be ready to find his top form heading into the winter months.
Recent form
Inter Milan: DWLWL
Napoli: LDWWW
Possible starting lineups
Inter Milan: Handanovic, Vidic, Dodo, D'Ambrosio, Juan, Hernanes, Medel, M'Vila, Kovacic, Palacio, Icardi
Napoli: Rafael, Albiol, Koulibaly, Maggio, Gargano, Zuniga, Inler, Michu, Higuain, Jose Callejon, Insigne
Sports Mole says: 1-2
Darren Plant
