Napoli vs. Udinese (Saturday, 2.00pm)
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Aiming to return to the Serie A summit - for a couple of hours, at least - Scudetto contenders Napoli welcome mid-table Udinese to Stadio Maradona on Saturday afternoon.
With leaders Milan not kicking off until the evening, Luciano Spalletti's side can go top with a win, but an increasingly resilient away side will stand in their path.
We say: Napoli 1-0 Udinese
Though their visitors have proved a tougher proposition recently than earlier this term, Napoli's need for the points is far greater.
That could even inhibit them, as has been the case on Neapolitan soil several times of late, so a close-fought encounter may be in store - with only the home side's attacking verve finally seeing them over the line.
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Inter Milan vs. Fiorentina (Saturday, 5.00pm)
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Seeking to apply pressure to their city rivals at the top of Serie A, Inter Milan welcome Fiorentina to San Siro on Saturday evening.
Trailing leaders Milan by four points - though still with a game in hand - the Scudetto holders are experiencing their first downturn in form for many months and will now meet an entertaining but unpredictable away side.
We say: Inter Milan 2-1 Fiorentina
Inter can get back on track with a victory this week, as Fiorentina do not tend to travel well, and their attacking approach may play into the champions' hands.
The Nerazzurri have scored the joint-most goals in the last 30 minutes of Serie A games this season (22), so another late strike such as last weekend's should not be discounted if the scores remain level heading towards stoppage time.
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Cagliari vs. AC Milan (Saturday, 7.45pm)
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Seeking to extend their unbeaten run to 10 games across all competitions, Serie A leaders AC Milan will travel to Sardinia to face Cagliari on Saturday night.
The hosts, meanwhile, are hovering just above the relegation zone and will be keen to avoid a third successive league defeat.
We say: Cagliari 0-2 AC Milan
Cagliari will be desperate to claim all three points as they aim to steer themselves further away from the relegation zone.
However, we cannot see the hosts getting the better of Milan, who should have enough quality in their side to secure a routine victory on Saturday.