Watford vs. Tottenham (Saturday, 12.30pm)
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Watford play host to Tottenham Hotspur in the Premier League on Saturday afternoon sitting outside of the relegation zone for the first time since August.
Meanwhile, Spurs make the short trip to Vicarage Road having failed to win any of their last three fixtures in the top flight, leaving Jose Mourinho's team in eighth position in the standings.
We say: Watford 2-1 Tottenham Hotspur
A month ago, Spurs would have been the favourites to prevail in this fixture. However, times have changed, and it would arguably come as a surprise if Mourinho's men ended their winless streak. Watford have been excellent in recent weeks and given the extra rest period, they should be better prepared to claim victory.
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> How Spurs could line up against Watford
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Arsenal vs. Sheffield United (Saturday, 3pm)
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Arsenal welcome Sheffield United to the Emirates Stadium on Saturday in the Premier League, with the Gunners looking to make up ground on their rivals ahead of them.
The Blades are currently four points clear of Mikel Arteta's side in the table and beat the North London club 1-0 in the reverse fixture at Bramall Lane in October.
We say: Arsenal 2-1 Sheffield United
Arsenal have had one of their poorest starts to a season in recent years, but with Arteta at the helm they should just have enough to see off Wilder's side. Having said that, it is set to be a fascinating tactical battle and do not rule out the Blades causing the Gunners problems.
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> How Arsenal could line up against Sheffield United
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Brighton vs. Aston Villa (Saturday, 3pm)
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Brighton & Hove Albion welcome Aston Villa to the American Express Community Stadium on Saturday, with both sides looking to move away from the relegation zone.
Brighton have improved with the ball under Graham Potter but remain just three points clear of the bottom three, while Villa sit 18th, one point adrift of safety.
We say: Brighton 1-1 Aston Villa
Both sides come into this fixture low on confidence and with injuries blighting their squads. As a result, expect a close, cagey affair, with neither side quite able to create enough chances to force a winner.
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Man City vs. Crystal Palace (Saturday, 3pm)
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Manchester City will be looking to make it six straight victories in all competitions when they welcome Crystal Palace to the Etihad Stadium in the Premier League on Saturday afternoon.
Pep Guardiola's side moved above Leicester City into second spot in the table last weekend, but they are still 14 points off leaders Liverpool, while Palace occupy ninth following a solid campaign to date.
We say: Manchester City 2-0 Crystal Palace
Palace's defensive record this season must be respected and therefore it is difficult to back a heavy City victory this weekend. Guardiola's team will enter the match as the overwhelming favourites, though, and we fully expect them to put another three points on the board.
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Norwich vs. Bournemouth (Saturday, 3pm)
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Norwich City and Bournemouth square off at Carrow Road on Saturday afternoon with the clubs occupying the bottom two places in the Premier League table.
While the home side sit eight points adrift of safety, the Cherries could move out of the dropzone with a welcome victory.
We say: Norwich City 2-1 Bournemouth
While this game is a difficult one to call, we have to go with home advantage. Despite both clubs struggling at both ends of the pitch, Bournemouth are not showing enough to suggest that they can avoid defeat to a team who have produced the majority of their best performances at Carrow Road.
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Southampton vs. Wolves (Saturday, 3pm)
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Southampton play host to Wolverhampton Wanderers on Saturday afternoon with the opportunity to move level on points with their opponents in the Premier League standings.
Meanwhile, Nuno Espirito Santo's side make the trip to St Mary's having failed to win any of their last five matches in all competitions.
We say: Southampton 2-0 Wolverhampton Wanderers
Given the respective momentum of the two clubs, this feels like an easy one to call. While Wolves will be desperate to get back on track as soon as possible, they may struggle to deal with a Southampton side who are now playing with a swagger.
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West Ham vs. Everton (Saturday, 3pm)
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David Moyes will be looking to get one over on one of his former clubs this weekend when West Ham United welcome Everton to the London Stadium in the Premier League.
The Hammers will enter the match in 16th spot in the table, just one point outside of the relegation zone, while Everton occupy 11th position having shown improvement under Carlo Ancelotti.
We say: West Ham 1-1 Everton
This is a tough match to call for a number of reasons. Everton would have fancied their chances of picking up a result in the latter stages of Manuel Pellegrini's tenure, but Moyes does seem to have improved confidence since returning to the London Stadium. We are tipping a low-scoring draw in the capital on Saturday afternoon.
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Newcastle vs. Chelsea (Saturday, 5.30pm)
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Chelsea make the trip to the North-East to face Newcastle United looking to strengthen their hold of fourth position in the Premier League standings.
While the Magpies head into the game having failed to win any of their last four games in the top flight, a 4-1 victory over Rochdale in the FA Cup has helped boost morale at St James' Park.
We say: Newcastle United 2-2 Chelsea
With Newcastle having found some confidence going forward, we feel that this will turn out to be a closely-fought contest. However, the Blues should be better for having no game in midweek, and that could lead to an entertaining draw being played out at St James' Park.
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> How Chelsea could line up against Newcastle
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Burnley vs. Leicester (Sunday, 2pm)
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Leicester City face Burnley on Sunday afternoon looking to return to winning ways in the Premier League after last weekend's defeat to Southampton.
Meanwhile, the Clarets welcome the Foxes to Turf Moor having lost four top-flight fixtures in a row - a run which has led to the club dropping to within three points of the relegation zone.
We say: Burnley 1-3 Leicester City
While Leicester have been below their best in recent weeks, this is the perfect opportunity to get back on track. Burnley, as usual, will produce a hard-working performance, but the visitors should have too much firepower in the final third.
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Liverpool vs. Man Utd (Sunday, 4.30pm)
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The two most successful clubs in English football history renew hostilities on Sunday when Premier League leaders Liverpool welcome bitter rivals Manchester United to Anfield.
Jurgen Klopp's side have shattered records galore while building a 14-point lead at the top of the table, but now come up against the only team to have taken points off them in the league so far this season.
We say: Liverpool 2-0 Manchester United
This is the first time Liverpool have hosted United in a league game while topping the table since September 1990, and they went on to win 4-0 on that occasion.
There will be some people expecting a similar scoreline this weekend, but United do seem to play better in these big games, whereas Liverpool often struggle to reach their own usual standard against their bitter rivals.
Nevertheless, we cannot back against a team which has been so relentless this season, particularly at Anfield. Anything other than a Liverpool win would be a major shock and, while it may not be as convincing as some expect, the hosts are overwhelming favourites for good reason.
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> How Liverpool could line up against Manchester United
> How Manchester United could line up against Liverpool
> Click here for Liverpool's latest injury and suspension news ahead of this match
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> Combined XI: Liverpool vs. Manchester United
> All-time Premier League combined XI: Liverpool vs. Manchester United
