Man Utd vs. Everton (Saturday, 12.30pm)
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Manchester United can extend their unbeaten run at Old Trafford to a staggering 24 games when they host Everton in Saturday lunchtime's Premier League contest.
The Red Devils rose back into the top four of the table with a 1-0 win over Brentford on Wednesday, while the Toffees remain above the dotted line thanks to a 1-1 draw with Tottenham Hotspur on Monday.
We say: Manchester United 1-0 Everton
Potentially setting up to frustrate Man United in a defence-heavy formation - especially considering their propensity to concede goals on the road - Dyche's Evertonian battlers can do exactly that against a fatigued Red Devils team.
However, for all of their worthwhile work at Goodison, Everton just cannot find the recipe for success on rival turf, and a Man United side who seldom give much away at Old Trafford can edge another low-scoring battle to strengthen their bid for a top-four finish.
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> How Man United could line up against Everton
> Man United injury, suspension list vs. Everton
Aston Villa vs. Nott'm Forest (Saturday, 3.00pm)
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Two sides moving in opposite directions face off in the Premier League on Saturday afternoon, as upwardly-mobile Aston Villa host free-falling Nottingham Forest.
The Villans have climbed to seventh following a run of five victories in six matches, while Forest are without a win in eight and find themselves outside the relegation zone on goal difference.
We say: Aston Villa 3-0 Nottingham Forest
Given the contrasting form of these two sides, Aston Villa look destined to heap more misery on Nottingham Forest, with Emery's men expected to inflict a fifth successive away defeat on the relegation strugglers.
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Brentford vs. Newcastle (Saturday, 3.00pm)
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Aiming to stretch their Premier League winning run to five matches, Newcastle United make a swift return to the capital to tackle Brentford on Saturday afternoon at the Gtech Community Stadium.
The Magpies demolished a disjointed West Ham United side 5-1 on Wednesday, while the Bees were put to the sword 1-0 by Manchester United at the same time in midweek.
We say: Brentford 1-2 Newcastle United
Newcastle may still proudly boast the stingiest defence in the league, but clean sheets have been hard to come by for Howe's side recently, so Brentford should certainly feel confident of making the net ripple in front of their own supporters.
The Bees' eye-catching record at the Gtech Community Stadium has served them well all season long, but victories have been drying up for Frank's side in recent weeks, and a Newcastle side who just cannot stop winning at present can inflict a second home loss of the season on the hosts to retain their place on the podium.
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Fulham vs. West Ham (Saturday, 3.00pm)
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Two out-of-sorts capital sides face off in a Premier League London derby on Saturday afternoon, as Fulham welcome West Ham United to Craven Cottage.
Marco Silva's side most recently went down 2-1 to relegation-threatened Bournemouth, while the Hammers' demotion fears deepened with a 5-1 loss to Newcastle United on Wednesday.
We say: Fulham 1-0 West Ham United
A spate of strong results against Fulham may give the Hammers faithful cause for optimism, while the absences of Silva and Mitrovic does not spell success for the leaky Cottagers either.
However, Moyes's men may already have one eye on their return to Conference League action and have been pitiful on the road all season long, so a re-energised Fulham can use their week's worth of rest to their advantage and return to winning ways by the narrowest of margins.
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Leicester vs. Bournemouth (Saturday, 3.00pm)
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A potentially pivotal clash between two relegation-threatened Premier League teams takes place at the King Power Stadium on Saturday, as managerless Leicester City play hosts to Bournemouth.
While the Foxes are seeking to avoid a fourth successive home defeat, the Cherries have lost eight of their last nine league matches on the road.
We say: Leicester City 1-2 Bournemouth
Considering four of the last five meetings between Leicester and Bournemouth have seen at least three goals scored, an entertaining end-to-end contest could be on the cards at the King Power Stadium.
Neither team will need reminding of how important securing maximum points on Saturday could be in their quest to avoid the drop, and while there is little to separate these two struggling sides, we feel that the Cherries may do just enough to come out on top.
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Spurs vs. Brighton (Saturday, 3.00pm)
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Fifth hosts sixth in an intriguing Premier League encounter on Saturday afternoon, as Tottenham Hotspur welcome Brighton & Hove Albion to North London.
Cristian Stellini's men were held to a 1-1 draw by Everton on Monday night, while the Seagulls' journey across the South Coast was a worthwhile one, as they eased past Bournemouth 2-0.
We say: Tottenham Hotspur 1-2 Brighton & Hove Albion
With Brighton possessing an affinity for 3pm goals and Spurs failing to keep the back door closed in afternoon contests - conceding an average of two per game at that time - the stage is set for a North London upset this weekend.
The injury-riddled Lilywhites experienced little in the way of a new manager bounce at Goodison Park, and with Brighton finding the back of the net for fun on rival territory, the Seagulls can feel wholly optimistic of coming away with all three points in the bag and sparking more furore in the capital.
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> How Tottenham could line up against Brighton
> Tottenham injury, suspension list vs. Brighton
Wolves vs. Chelsea (Saturday, 3.00pm)
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Frank Lampard will begin his reign as Chelsea's caretaker manager with a trip to Molineux to face Wolverhampton Wanderers in the Premier League on Saturday.
While the West Londoners are languishing in 11th place in the table and are at risk of failing to qualify for Europe, Wolves are positioned three places further back in 14th and are fighting against relegation.
We say: Wolverhampton Wanderers 0-1 Chelsea
The pressure is on both teams to end their poor runs of form and pick up precious points on Saturday if they wish to meet their respective targets this season.
Wolves have impressed in big games on home soil this season, but the return of Lampard to Chelsea could provide his squad with a much-needed boost to come out on top at Molineux and kick-start a charge for Europe.
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> How Chelsea could line up against Wolves
> Chelsea injury, suspension list vs. Wolves
Southampton vs. Man City (Saturday, 5.30pm)
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Seeking to remain in touch with Premier League leaders Arsenal, reigning champions Manchester City travel to St Mary's to face basement club Southampton on Saturday evening.
While the Citizens have picked up 10 points from their last four top-flight away games, the Saints have accumulated the same number of points across their 14 home matches this season – the fewest of any team in the division.
We say: Southampton 0-3 Manchester City
Despite suffering defeat in their last visit to St Mary's, Man City will be regarded as strong favourites to claim maximum points on Saturday and boost their hopes of closing the gap to leaders Arsenal.
City demonstrated their clinical qualities in front of goal without the presence of Haaland in the win over Liverpool, but the Norwegian's potential return is sure to frighten a Saints side who are struggling to both score and grind out positive results in their quest to avoid the drop.
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