Manchester United manager Sir Alex Ferguson has handed Darren Fletcher his first Premier League start of the season.
The Scotland captain, who has just recovered from a virus, will partner Anderson in central midfield.
For visiting Chelsea, Fernando Torres starts in a lone striking role.
Daniel Sturridge and Juan Mata will provide Torres with support from either flank.
Man United: De Gea; Smalling, Evans, Jones, Evra; Nani, Fletcher, Anderson, Young; Rooney, Hernandez.
Chelsea: Cech; Bosingwa, Ivanovic, Terry, Cole; Meireles, Ramires, Lampard; Sturridge, Torres, Mata.
