Sunderland vs. Portsmouth (Saturday, 3.00pm)
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A Premier League fixture as little as 12 years ago, both Sunderland and Portsmouth will look to take three points in their search for promotion when the pair meet on Saturday afternoon.
The hosts remain in the automatic mix, while the visitors will travel to the North East desperate to stay in touch with their fellow playoff challengers.
We say: Sunderland 2-1 Portsmouth
In a clash that could define who secures promotion and who misses out come the end of the season, both sides will be hopeful of three points.
Sunderland boast home advantage, along with the superior league position, making the Black Cats the most likely winners for this one.
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Wigan vs. Gillingham (Saturday, 3.00pm)
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Two teams with contrasting ambitions for the remainder of the season, Wigan Athletic will look to continue their push for promotion when relegation candidates Gillingham visit Lancashire on Saturday afternoon.
The hosts could find themselves top of the table by the end of play, should other results go their way, while the visitors remain in a relegation scrap.
We say: Wigan Athletic 3-0 Gillingham
Wigan may have the luxury of games in hand, but it is points on the board that will see the Latics return to the Championship.
A triumph over struggling Gillingham will represent another key step on their journey back to the second tier, and the home side are well placed to take all three points on Saturday.
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Ipswich vs. Accrington (Saturday, 3.00pm)
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Two sides in pursuit of the League One playoff places will square off on Saturday, as Ipswich Town welcome Accrington Stanley to Portman Road.
After a defeat for the home side last weekend, John Coleman's men sit one point and one place ahead of their hosts in 10th spot in the League One table.
We say: Ipswich Town 1-1 Accrington Stanley
While Ipswich boast one of the strongest squads in the league, Accrington Stanley have shown themselves to be resilient recently, and, on the back of an impressive run, we back them to leave Portman Road with a valuable point.
The Tractor Boys will certainly pose a major threat to Coleman's men, but Stanley have neutralised some impressive attacks and will fancy themselves to match the hosts who have struggled for consistency.
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Charlton vs. Fleetwood (Saturday, 3.00pm)
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Charlton Athletic will be aiming to end a four-game winless league run, when they welcome Fleetwood Town to the Valley on Saturday.
Meanwhile, the visitors are riding a crest of a wave after claiming consecutive 1-0 victories and could leapfrog their opponents in the League One table with a victory.
We say: Charlton Athletic 1-1 Fleetwood Town
Charlton have struggled in recent weeks, and on Saturday they face a Fleetwood side who will be full of confidence after winning their last two matches.
Three out of the last four meetings between the two sides at the Valley have ended level, and we think Saturday's contest will result in another encounter ending all square.
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MK Dons vs. Doncaster (Saturday, 3.00pm)
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Sides at opposite ends of the League One table will lock horns on Saturday, as MK Dons welcome Doncaster Rovers to Stadium MK.
The hosts have established themselves in the playoff places with a five-game unbeaten run, while their visitors are stuck to the foot of the division.
We say: MK Dons 2-0 Doncaster Rovers
Given the form and quality of the two sides, we can only envisage a relatively comfortable home victory on Saturday.
MK Dons have taken huge strides this season, excelling at both ends of the pitch, and they should cruise past the basement side given their impressive momentum.
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Rotherham vs. Cheltenham (Saturday, 3.00pm)
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After losing last weekend, Rotherham United will look to get their promotion bid back on track, when they welcome Cheltenham Town to the New York Stadium on Saturday.
The visitors, who sit in 14th place in League One, are aiming to end a nine-game winless run across all competitions.
We say: Rotherham United 3-1 Cheltenham Town
The Millers usually fare well on home turf, and we do not see that changing at the weekend, when they come up against a Cheltenham side that are struggling to pick up wins.
Rotherham have found the net with ease at home in recent times, and we think they will be amongst the goals once again on Saturday.
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Plymouth vs. Lincoln (Saturday, 3.00pm)
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Two teams at different ends of the League One table will meet on Saturday as sixth-placed Plymouth Argyle welcome Lincoln City to Home Park.
The visitors are just three places above the relegation zone right now, and will be looking to bounce back from their recent defeat last weekend.
We say: Plymouth Argyle 2-1 Lincoln City
Plymouth Argyle head into this match as firm favourites, but the visitors have been impressive since the turn of the year, and that is something they shall be trying to continue.
Ultimately, the home side should have just enough quality and confidence to edge this one, but it will likely be a hard-fought victory.
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Oxford Utd vs. Sheff Weds (Saturday, 3.00pm)
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A crucial clash in the race for spots in the top six of the League One table will take place at the Kassam Stadium on Saturday, as Oxford United host Sheffield Wednesday.
Back-to-back defeats have seen the hosts drop out of the playoffs in recent weeks, while the Owls boosted their own bid with a victory over Plymouth Argyle on Saturday.
We say: Oxford United 1-2 Sheffield Wednesday
Sheffield Wednesday looked rejuvenated in their clash with Plymouth, and, on the back of that confidence-building win, we see them taking all three points from an Oxford side struggling for form.
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Shrewsbury vs. Bolton (Saturday, 3.00pm)
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After ending a run of five consecutive defeats in all competitions last weekend, Bolton Wanderers will be aiming to claim consecutive victories, when they travel to Shropshire for a League One contest against Shrewsbury Town.
The hosts, meanwhile, are currently enjoying a fine spell of form that has seen them avoid defeat in their last five league games.
We say: Shrewsbury Town 1-1 Bolton Wanderers
Shrewsbury are currently in a rich vein of form, and they will face a Bolton side bouyed by last weekend's victory, and with the two teams separated by just a point in the table, we think they will cancel each other out on Saturday.
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Burton Albion vs. AFC Wimbledon (Saturday, 3.00pm)
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Burton Albion shall be attempting to continue their three-match undefeated run on Saturday when they host AFC Wimbledon at the Pirelli Stadium.
The visitors currently sit just above the League One relegation zone, and they are without a win in six matches across all competitions.
We say: Burton Albion 2-0 AFC Wimbledon
Wimbledon desperately need to secure some points at the moment due to the fact a loss could drop them into the relegation zone, but this fixture will not be an easy one.
Burton are enjoying a great start to the New Year, and with their current confidence, that could see them secure a victory, especially due to their attacking abilities.
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Morecambe vs. Wycombe (Saturday, 3.00pm)
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Wycombe Wanderers will look to keep their place at the top of the League One table on Saturday, when they travel to take on Morecambe.
Back-to-back wins have seen Gareth Ainsworth's side climb to the summit of the English third tier, while their hosts sit in the drop zone after a tough first half to the campaign.
We say: Morecambe 0-1 Wycombe Wanderers
While Morecambe have been more resilient in recent outings, Wycombe seem to have kicked into gear in their bid for promotion, and we expect them to get the job done on Saturday.
Ainsworth's men have excelled in grinding out wins from tough clashes, and we see that happening this weekend against a Shrimps side full of fight.
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Cambridge vs. Crewe (Saturday, 3.00pm)
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Two sides who may have expected to be in the middle of a relegation battle at this point in the campaign, Cambridge United will welcome Crewe Alexandra to the Abbey Stadium looking to pull further clear of the drop zone.
Sitting comfortably in mid-table, the hosts can pull even closer to the top half of the table with a victory over relegation-threatened Crewe.
We say: Cambridge United 1-0 Crewe Alexandra
While Crewe may be on the up, there are few sides in the division enjoying their football more than Cambridge at this moment.
With safety seemingly around the corner for the U's, expect them to continue their strong form this weekend.