Wales star George North is out of contention for the British and Irish Lions tour of South Africa after confirming he has suffered a serious knee injury.
It is a major blow for Lions head coach Warren Gatland, who names his squad next week.
North was hurt during Ospreys' victory over Cardiff Blues last weekend, and he tweeted: "Sport can be cruel.
Sport can be cruel. We all know the risks when we take the field. Unfortunately I ruptured my ACL on Saturday and will need surgery next week. Heartbroken is an understatement. 💔 pic.twitter.com/icNDEmYmHE — George North (@George_North) April 28, 2021
"We all know the risks when we take the field. Unfortunately, I ruptured my ACL (anterior cruciate ligament) on Saturday and will need surgery next week. Heartbroken is an understatement."
The normal recovery period for such an injury is six-nine months.
The Ospreys said: "The Ospreys can confirm wing George North has suffered an ACL injury to his right knee and will be ruled out for the rest of the season.
"The Wales wing saw a specialist in London earlier this week and will undergo surgery next week."
Ospreys can confirm wing @George_North has suffered an ACL injury to his right knee and will be ruled out for the rest of the season. Wishing him the speediest of recoveries 💪 — Ospreys (@ospreys) April 28, 2021
North was widely tipped for a starting place in Gatland's Test team against the world champion Springboks.
He had been switched from wing to outside centre with great success by Wales head coach Wayne Pivac this season and played a key role in Wales' Guinness Six Nations title-winning campaign.
North has won 102 caps for Wales and played in all three Lions Tests against Australia eight years ago.
The 29-year-old also toured with the Lions to New Zealand in 2017, but he was not involved during the Test series.
He would have offered Gatland a considerable physical presence in midfield and a major try-scoring threat.
North has collected 43 tries during his 11-year Wales career, with only Shane Williams scoring more.
But he now faces a lengthy period of rehabilitation, having seen his Lions hopes ended in the cruellest fashion.
Reflecting on North's injury, Gatland told BBC Jersey: "It's a big blow for the Lions and a big blow for George as well.
"I feel for him and wish him a speedy recovery, and hopefully he can get back to full fitness and get quickly to playing international rugby.
🏥 @joe_launch Injury Update Joe Launchbury has a complete rupture of his Anterior Cruciate Ligament (ACL)... A consultation with a knee specialist confirmed that he will require surgery. 🐝 Everyone at Wasps wishes Joe all the best for a speedy recovery. pic.twitter.com/M2rN9aqD5o — Wasps Rugby (@WaspsRugby) April 27, 2021
"We've got to realise we've got two or three players that aren't going to make the tour because they've got injuries.
"I presume between now and when we get on the plane and fly out to South Africa, we are going to pick up one or two others as well."
It is the second setback in 24 hours for Gatland after Wasps and England lock Joe Launchbury saw his Lions selection hopes ended, also by a ruptured knee ligament.
Gatland is due to name the Lions squad on May 6.
