Unbeaten Saracens head to Devon on Sunday to face the Exeter Chiefs.
Scrum-half Neil de Kock starts in his 150th appearance for Saracens while former England captain Steve Borthwick is named on the bench.
England prop Matt Stevens is lined up to make his first appearance of the season having also being named amongst the Saracens replacements.
Exeter absentees Craig Mitchell and Tom Johnson are replaced in the pack by Carl Rimmer and James Phillips while Haydn Thomas has been given his first start at scrum-half.
Chiefs director of rugby Rob Baxter said: "They are a very good side and we've only beaten them once in the four times we've played them in the Premiership.
"But there are a lot of teams with a similar record against them. They play a very attritional style of rugby, which can be tough to break down, and it will be a great test for us."
Lineups:
Exeter Chiefs: Arscott, Dollman, Whitten, Naqelevuki, Jess, Mieres, Thomas, Sturgess, Whitehead, Rimmer, Hayes, Hanks, Phillips, Scaysbrook, Baxter
Saracens: Goode, Ashton, Taylor, Barritt, Short, Farrell, de Kock, Vunipola, George, Nieto, Hargreaves, Botha, Brown, Fraser, Wray
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