Defending champion Novak Djokovic and five-time winner Roger Federer made it through to round four.
Johanna Konta is the last Brit standing having made the second week for a third straight grand slam.
Here, PA looks back at day five and forward to day six at the US Open.
Shot of the day
These reactions from @alexdeminaur... 💯 The 🇦🇺 will meet Grigor Dimitrov or Kamil Majchrzak for a place in the #USOpen quarter-finals. 👊 🎥: @usopenpic.twitter.com/WsncDaapzn — ATP Tour (@ATP_Tour) August 30, 2019
Alex de Minaur's pick-up and volley had the Grandstand crowd on its feet.
Quote of the day
Shock of the day
He's got hops 🦘@alexdeminaur upsets No. 7 seed Kei Nishikori 6-2, 6-4, 2-6, 6-3 to reach his first career Grand Slam R4.#USOpen pic.twitter.com/mBoO184WmY — US Open Tennis (@usopen) August 30, 2019
Seventh seed Kei Nishikori, a finalist here in 2014, was dumped out in four sets by Australian De Minaur.
Brit watch
Dan Evans' exertions in his rain-delayed second-round match caught up with him as he bowed out to Roger Federer, winning just five games. But Johanna Konta marches on after a straight-sets win over Zhang Shuai.
Teen spirit
Jumping into R2 of doubles like... 🤣 Coco Gauff & Caty McNally defeat Siniaková & Görges 7-6(6), 6-2!@CocoGauff | @CatyMcNally | #USOpen pic.twitter.com/plka6h3xwz — US Open Tennis (@usopen) August 30, 2019
Coco Gauff and Caty McNally thrilled a packed Court Five with their sojourn into the doubles, a 7-6 6-2 win over Julia Goerges and Katerina Siniakova.
Fallen seeds
Men: Kei Nishikori (7), Nikoloz Basilashvili (17)
Women: Anastasia Sevastova (12), Sofia Kenin (20), Maria Sakkari (30), Dayana Yastremska (32), Zhang Shuai (33)
Saturday's order of play
Arthur Ashe Stadium:
Caroline Wozniacki v Bianca Andreescu
Hyeon Chung v Rafael Nadal
Naomi Osaka v Coco Gauff
Andrey Rublev v Nick Kyrgios
Louis Armstrong Stadium:
Taylor Townsend v Sorana Cirstea
Julia Goerges v Kiki Bertens
Alexander Zverev v Aljaz Bedene
Gael Monfils v Denis Shapovalov
