Harlequins prop Kyle Sinckler will miss the remainder of the season due to a knee ligament injury sustained against Saracens last weekend.
The 22-year-old, who signed a new deal at the club earlier this year to keep him in place until 2017, was on the end of a heavy tackle from Jacques Burger during the 42-14 defeat at Wembley.
Quins coach Conor O'Shea admitted to being left "massively frustrated" by the setback when talking to reporters after the game, which will leave him without his tight-head until next season.
Sinckler has made 52 appearances for Harlequins since breaking into the first-team fold.