This encounter was a regular Premier League fixture during the 1990s.
However, both sides have endured mixed fortunes over the past few seasons and as a result find themselves in the Championship.
Of the 70 previous meetings, Blackburn Rovers have won 34 times, with Sheffield Wednesday emerging victorious on 18 occasions.
Reports have claimed that Blackburn's interim manager Eric Black will not make any changes to his squad for the visit of Wednesday.
Meanwhile, Chris Kirkland is expected to keep goal for the Owls on Wednesday despite being the victim of an assault during his side's 1-1 draw with Leeds United last Friday night.
Recent form
Blackburn: DLDLL
Sheff Wed: WDDLWW
Possible starting lineups:
Blackburn: Robinson; Orr, Martin Olsson, Givet, Dann; Murphy, Dunn, Pedersen, Etuhu; Rhodes, Kazim-Richards
Sheff Wed: Kirkland; Buxton, Gardner, D Jones, Llera; Semedo, Antonio, Corry, Barkley; Madine, Bothroyd
Sports Mole says: 2-0
