West Ham vs. Man Utd (Sunday, 2.00pm)
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Manchester United will be looking to bounce back from Champions League disappointment when they continue their 2021-22 Premier League campaign away to West Ham United on Sunday afternoon.
The Red Devils suffered a 2-1 loss to Young Boys in their opening group-stage fixture on Tuesday, but West Ham started their Europa League challenge with an impressive 2-0 success away to Dinamo Zagreb.
We say: West Ham United 1-2 Manchester United
This is an incredibly difficult match for Man United, but the absence of Antonio for West Ham is a huge boost for Solskjaer's side. It would not be a surprise to see a home victory or a draw at the London Stadium, but we just have a feeling that the Red Devils will do enough to secure a narrow win in the capital, having had longer to prepare for the contest.
> Click here to read our full preview for this match
> How Man United could line up against West Ham
> Man United injury, suspension list vs. West Ham
> How West Ham could line up without Antonio against Man United
Brighton vs. Leicester (Sunday, 2.00pm)
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Leicester City will be looking to return to winning ways in the Premier League when they head to the Amex on Sunday afternoon to take on Brighton & Hove Albion.
The Foxes are currently ninth in the table with six points to show from their four matches, while Brighton occupy sixth, having picked up nine points from their first four fixtures of the 2021-22 campaign.
We say: Brighton & Hove Albion 2-2 Leicester City
Leicester are struggling to gain any sort of momentum in the early stages of the season, and they will be taking on a Brighton side full of confidence following a strong start. We are expecting goals at the Amex on Sunday and have had to settle on a draw taking everything into consideration.
> Click here to read our full preview for this match
Spurs vs. Chelsea (Sunday, 4.30pm)
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Having posted contrasting results in their opening European encounters, Tottenham Hotspur and Chelsea prepare for battle in an eye-catching London derby in the Premier League on Sunday afternoon.
The hosts played out a 2-2 draw with Rennes in the Europa Conference League in midweek, whereas Chelsea started their Champions League defence with a 1-0 success over Zenit St Petersburg.
We say: Tottenham Hotspur 0-1 Chelsea
Spurs' injury problems in attack are mounting, but the potential returns of Sanchez and Romero will at least ease their concerns on the defensive front before Tuchel's rampant forces pay a visit.
It is difficult to envisage Chelsea banking multiple goals in the capital if Santo has his first-choice backline available, but the visitors' own staunch rearguard action should shine through as they scrape a narrow win at the Tottenham Hotspur Stadium.
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> How Chelsea could line up against Tottenham
