Portugal are 45 minutes away from going top of Group I in their Euro 2016 qualifying campaign after taking in a 1-0 lead at the break at home to Serbia in Lisbon.
Ricardo Carvalho gave the hosts the lead inside the first 10 minutes when he rose highest to head home a cross from Real Madrid's Fabio Coentrao.
Carvalho's evening was short-lived however, and the Monaco centre-back was forced off on 17 minutes with a hamstring injury.
Southampton winger Dusan Tadic almost restored parity but his powerful effort flashed just wide of the post before the half-hour mark.
Cristiano Ronaldo then went close with a well-struck effort from range, but the Real Madrid forward was denied by a good save from goalkeeper Vladimir Stojkovic.
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